麻醉学中应激与适应理论的转变。实际应用的观点还是怀疑?(文献综述)

V. Y. Lysenko
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引用次数: 0

摘要

本文试图分析应激与适应理论在现代的主要转变,以及全麻实施抗应激适应反应的可能性。应激源损伤的中心非特异性机制之一已被发现是由于经常伴随的低氧血症/缺氧和儿茶酚胺的促氧化作用而导致自由基过程的刺激。介绍了FR产物(AOS和氮)在调节基因表达和增加抗应激蛋白的产生、刺激线粒体生物发生和正常化能量代谢方面的调节和适应作用的数据。本文给出了适应学的“辩护者”对适应类型的“整体”指标和有机体功能状态的讨论。重点放在麻醉师对有机体是一个相对开放的自组织和自结构耗散系统的理解上,以及对评估有机体适应过程的数学方法的批判性观点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ANESTHESIOLOGY IN THE LIGHT OF THE TRANSFORMATIONS OF THE THEORY OF STRESS AND ADAPTATION. PERSPECTIVE OR SKEPTICISM OF PRACTICAL USE? (literature review)
The article attempts to analyze the main modern transformations of the theory of stress and adaptation and the possibility of implementing anti-stress adaptation reactions of general anesthesia. One of the central non-specific mechanisms of stressor injury has been found to be the stimulation of free-radical processes as a result of the often concomitant hypoxemia / hypoxia and the prooxidant effects of catecholamines. Data on the regulatory and adaptive effect of FR products (AOS and nitrogen) in the regulation of gene expression and increased production of antistress proteins, stimulation of mitochondrial biogenesis and normalization of energy metabolism are presented. The discussions of the "apologists" of adaptology about the "integral" indicators of the type of adaptation and the functional state of the organism are given. Emphasis is placed on the anesthesiologist's understanding that the organism is a relatively open selforganizing and self-structured dissipative system, as well as a critical view of the mathematical method of evaluating adaptation processes in the organism.
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