孕期药物滥用

Olivia Grubman, F. Hussain, L. Brustman
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摘要

物质使用障碍(SUD)被许多产科医生认为是一个最好由其他学科管理的问题。然而,这也是我们不可避免的问题。所有的医生都有可能给育龄妇女开过量的养成习惯的药物妇产科医生具有独特的优势,可以成为受SUD影响的患者的捍卫者,因为产前护理的结构使其成为参与医疗护理的紧张时期,在此期间,妇女有独特的动力来优化自己的健康有了适当的教育和工具,产科医生就完全有能力识别和治疗SUD。SUD对女性的影响尤为严重。2014年药物滥用和精神健康服务管理局(SAMHSA)的一份报告显示,在所有年龄段,女性因阿片类止痛药(作为主要滥用物质)接受治疗的人数都超过了男性怀孕期间阿片类药物使用率为每1000例活产5.6例4,一项研究报告> 85%的阿片类药物使用障碍妇女的怀孕是意外的5阿片类药物使用障碍不仅严重影响孕产妇和儿童健康,而且对社会的经济影响也很大。2009年,新生儿戒断综合征的费用为7.2亿美元,2015年增加到15亿美元,其中80%的费用由医疗补助系统产生。为了优化对患有SUD的孕妇的护理,重要的是要了解它是一个独立于妊娠的疾病过程。SUD是一种原发性慢性脑奖励、动机、记忆及相关回路疾病。与其他慢性疾病如慢性高血压、II型糖尿病和哮喘一样,如果不进行治疗或不参与康复活动,SUD是进行性的,可导致残疾或过早死亡。这些慢性疾病,包括SUD,都有类似的特点:它们可以通过药物和干预治疗,它们容易复发,复发率为
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Substance Abuse in Pregnancy
Substance use disorder (SUD) is considered by many obstetricians to be a problem best managed by other disciplines. However, it is inevitably our problem as well. All physicians have likely contributed to overprescribing habit-forming medications to women of childbearing age.1 Obstetrician-gynecologists are uniquely positioned to be champions for those affected by SUD as the structure of prenatal care lends itself to an intense time of engagement in medical care during which women are uniquely motivated to optimize their health.2 With the proper education and tools, obstetricians stand to be fully equipped to identify and treat SUD. SUD affects women disproportionately. A 2014 Substance Abuse andMental Health Services Administration (SAMHSA) report showed female treatment admissions for opioid pain relievers (as the primary substance of abuse) outnumber male admissions in all age categories.3 The rate of opioid use during pregnancy is ∼5.6 per 1000 live births,4 with one study reporting > 85% of pregnancies in women with opioid use disorder were unintended.5 Not only has opioid use disorder significantly impacted maternal and child health, but the financial impact to society is high as well. In 2009, the cost of neonatal abstinence syndrome alone was $720,000,000 which increased to $1.5 billion in 2015.4,6 Of that, ∼80% of cost is incurred by Medicaid systems. To optimize the care of pregnant women with SUD, it is important to understand it as a disease process independent of pregnancy. SUD is a primary, chronic disease of brain reward, motivation, memory, and related circuitry. Similar to other chronic diseases such as chronic hypertension, type II diabetes, and asthma, without treatment or engagement in recovery activities, SUD is progressive and can result in disability or premature death. Such chronic diseases, including SUD, carry similar hallmarks: they are treatable with medications and intervention, they are prone to relapse at a rate of
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