Nuala Beahan, Emma Reichman, J. Kei, C. Driscoll, June Young, R. Suppiah, Mary-Lou Grohn, R. Sockalingam, B. Charles
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引用次数: 6
摘要
本研究的目的是检查耳毒性听力损失儿童化疗期间畸变产物耳声发射(dpoae)的变化模式。对照组15例正常听力儿童(3 ~ 12岁)，实验组7例儿科肿瘤患者(1 ~ 13岁)。参与者使用纯音测听法(PTA)、鼓室测听法和dpoae(初级65/55 dB SPL)进行测试。结果表明，PTA与DPOAE结果在频率和DPOAE振幅减小/增加的模式上没有完全匹配。进一步分析实验组的dpoae，发现了三种主要的变化模式:(1)dpoae同时下降，与纯音阈值(PTT)的变化大致相同;(2) DPOAE变化先于PTT变化，提示DPOAE检测可能具有预测能力;(3)在卡铂累积剂量高的患者中，DPOAE与PTT变化在检测频率和变化方向上不相关。
DPOAE Changes in Young Children with Confirmed Hearing Loss Due to Ototoxicity
The aim of this study was to examine the pattern of changes in distortion product otoacoustic emissions (DPOAEs) in children with ototoxic hearing loss during chemotherapy. The participants included a control group of 15 normal hearing children (3-12 years) and an experimental group of 7 paediatric oncology patients (1-13 years). Participants were tested using pure tone audiometry (PTA), tympanometry, and DPOAEs (primaries 65/55 dB SPL). The results revealed no perfect match between PTA and DPOAE results with respect to frequency and pattern of decrease/increase of DPOAE amplitudes. Further analysis of DPOAEs in the experimental group revealed three main patterns of change: (1) Concurrent decreases in DPOAEs that matched pure tone threshold (PTT) changes at approximately the same frequencies; (2) DPOAE changes prior to PTT change, suggesting possible predictive power in DPOAE testing and (3) DPOAE and PTT changes not related in terms of test frequency and direction of change, noted in a patient with a high cumulative carboplatin dose.
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