自身抗体:自身免疫性不孕症的关键介质

Kaushiki Kadam, P. Mande, Asmita K Choudhury
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引用次数: 1

摘要

自身免疫性疾病有性别偏见,以女性为主,自身免疫性推断(AI)也不例外。本章将重点讨论女性的AI,并简要介绍男性的AI。自身免疫性疾病已经建立了检测和治疗不孕症的方案,但是对于不明原因的不孕症[输卵管阻塞、子宫内膜异位症、卵巢早衰(POI)、未确诊的潜在自身免疫性疾病(Sjögren综合征、肠易激综合征、乳糜泻)和输卵管阻塞]的类似方案尚未建立。特别是子宫内膜异位症和POI,具有自身免疫性病因,但缺乏特异性和敏感的生物标志物来准确诊断。如果确实诊断出自身抗体,那么治疗方案将侧重于已知副作用的人工智能。作为自身抗体的天然抗体的检测为更好地管理人工智能提供了一种可行的替代器官特异性生物标志物面板。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Autoantibodies: Key Mediators of Autoimmune Infertility
Autoimmune diseases have gender bias with predominance in females, autoimmune infer- tility (AI) being no exception. This chapter will focus on AI in females with brief reference to the same in males. Autoimmune diseases have established protocols for detection and management of ensuing infertility, however similar protocols for unexplained infertility [tubal blockage, endometriosis, premature ovarian insufficiency (POI), undiagnosed under- lying autoimmune disease (Sjögren ’ s syndrome, IBS, celiac disease) and tubal blockage] are not established. Endometriosis and POI, in particular, have autoimmune etiology yet lack specific and sensitive biomarkers for accurate diagnosis. If autoantibodies are indeed diagnosed, then treatment regimen focuses on AI which has known adverse effects. The detec- tion of natural antibodies as autoantibodies presents a viable alternative to organ specific biomarker panel for better management of AI.
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