P. Roy, Samadrita Bhattacharya, H. Rahaman, P. Dasgupta
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引用次数: 0
摘要
基于微流控的生物芯片作为一种复合微系统,为传统的实验室程序提供了一种替代平台。近年来,新一代的芯片实验室设备,即数字微流控生物芯片,作为多种生物检测协议的并发和可扩展集成的合适应用而出现。可靠性和准确性是dmfb安全关键应用的主要问题,特别是在临床诊断和其他生化应用领域。功能测试的目标是评估基本微流体操作的可靠性,即合并、混合、分裂和孵育。在本文中,我们提出了一种布局特定的功能测试方法,该方法可以检测已经放置在2D阵列中的预先指定的细胞组中的故障,以执行给定的生物测定方案。目标是最大限度地减少测试完成时间,优化测试资源,并为预先指定的细胞群定制测试,这些细胞群将用作专用于微流体操作的模块。在Benchmark suite III的试验台上进行了仿真,结果令人鼓舞。
A new technique for layout based functional testing of modules in Digital Microfluidic Biochips
Microfluidic based biochips as a composite microsystem offers an alternative platform for conventional laboratory procedures. In recent years a new generation of such lab on chip devices namely Digital Microfluidic Biochip is emerged as a suitable application for concurrent and scalable integration of multiple bioassay protocols. Dependability and accuracy are major issues for safety critical applications of DMFBs specifically in the areas of clinical diagnostics and other biochemical applications. Functional testing is targeted towards assessment of reliability of basic microfluidic operations namely merging, mixing, splitting and incubation. In this paper we proposed a layout specific functional testing method that detects faults in a prespecified group of cells already placed within a 2D array for execution of a given bioassay protocol. The objective is to minimize the test completion time, optimize test resources and customize the test for prespecified cluster of cells to be utilized as modules dedicated for microfluidic operations. The simulation is carried out on testbenches of Benchmark suite III and the results are found to be encouraging.