{"title":"5 -羟色胺C1a受体激动剂肉肉素亚型对大鼠动脉压的影响。","authors":"A I Piianzin, N K Popova, A L Markel'","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The effect of a high-affinity C1A serotonin receptor agonist flesinoxan on the arterial blood pressure and the heart rate in normotensive Wistar rats, spontaneously hypertensive rats and inherited stress-induced arterial hypertension rats was studied. It was shown that both peripheral and central administration of flesinoxan produces a decrease of blood pressure and heart rate. However, a reduction of heart rate was more pronounced at the drug peripheral administration. The sensitivity to flesinoxan in the hypertensive rats was greater than in the normotensive rats.</p>","PeriodicalId":12237,"journal":{"name":"Farmakologiia i toksikologiia","volume":"54 4","pages":"28-30"},"PeriodicalIF":0.0000,"publicationDate":"1991-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[The effect of the flesinoxan subtype of serotonin C1a receptor agonist on the arterial pressure in rats].\",\"authors\":\"A I Piianzin, N K Popova, A L Markel'\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The effect of a high-affinity C1A serotonin receptor agonist flesinoxan on the arterial blood pressure and the heart rate in normotensive Wistar rats, spontaneously hypertensive rats and inherited stress-induced arterial hypertension rats was studied. It was shown that both peripheral and central administration of flesinoxan produces a decrease of blood pressure and heart rate. However, a reduction of heart rate was more pronounced at the drug peripheral administration. The sensitivity to flesinoxan in the hypertensive rats was greater than in the normotensive rats.</p>\",\"PeriodicalId\":12237,\"journal\":{\"name\":\"Farmakologiia i toksikologiia\",\"volume\":\"54 4\",\"pages\":\"28-30\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1991-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Farmakologiia i toksikologiia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Farmakologiia i toksikologiia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[The effect of the flesinoxan subtype of serotonin C1a receptor agonist on the arterial pressure in rats].
The effect of a high-affinity C1A serotonin receptor agonist flesinoxan on the arterial blood pressure and the heart rate in normotensive Wistar rats, spontaneously hypertensive rats and inherited stress-induced arterial hypertension rats was studied. It was shown that both peripheral and central administration of flesinoxan produces a decrease of blood pressure and heart rate. However, a reduction of heart rate was more pronounced at the drug peripheral administration. The sensitivity to flesinoxan in the hypertensive rats was greater than in the normotensive rats.
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