Clinical Images

This 42-year-old male, a known case of human immunodeficiency virus infection and acquired immunodeficiency syndrome on antiretroviral therapy, presented to our department with the complaint of fever, cough, and increasing shortness of breath over the last 2 weeks. On examination, there was hypoxemia (peripheral arterial oxygen saturation of 82% on room air) with a few crackles in both lung bases. Computerized tomography (CT) of the chest revealed the area of central ground-glass opacity that was surrounded by a denser consolidation of a crescentic shape, suggesting “Reversed halo sign” (Fig. 1). Bronchoalveolar lavage and bronchoscopy guided biopsy showed lung tissue filled with colonies of broad, nonseptate right-angled branching fungal hyphae. A diagnosis of pulmonary mucormycosis was done on histopathology. There was no evidence of other common opportunistic infections. He had been diagnosed as a case of pulmonary Mucormycosis and started on liposomal amphotericin B; however, we lost the patient within the next few days despite our best effort.