{"title":"心梗果提取物对大鼠心肌缺血再灌注损伤的保护作用","authors":"S. M. Asdaq, S. Prasannakumar","doi":"10.5580/1a35","DOIUrl":null,"url":null,"abstract":"The purpose of the present study was to identify bioactivity in ethanolic extract of Semecarpus anacardium (EESA) fruits on experimentally induced myocardial damage in rats. The excised heart from previously treated rats was mounted and subjected to ischemia-reperfusion injury (IRI). The high dose of EESA significantly decreases endogenous biomarker enzymes such as LDH and CK-MB activities in perfusate and increases in heart tissue homogenate (HTH). Moreover, biological antioxidants viz., SOD and catalase activities were significantly increased in HTH. High dose of EESA were also found to provide significant recovery in developed tension and heart rate from ischemia. The biochemical findings were confirmed by histological investigations.","PeriodicalId":107168,"journal":{"name":"The Internet Journal of Alternative Medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2008-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Protective effects of Semecarpus anacardium fruit extract against myocardial ischemia-reperfusion injury in rats\",\"authors\":\"S. M. Asdaq, S. Prasannakumar\",\"doi\":\"10.5580/1a35\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The purpose of the present study was to identify bioactivity in ethanolic extract of Semecarpus anacardium (EESA) fruits on experimentally induced myocardial damage in rats. The excised heart from previously treated rats was mounted and subjected to ischemia-reperfusion injury (IRI). The high dose of EESA significantly decreases endogenous biomarker enzymes such as LDH and CK-MB activities in perfusate and increases in heart tissue homogenate (HTH). Moreover, biological antioxidants viz., SOD and catalase activities were significantly increased in HTH. High dose of EESA were also found to provide significant recovery in developed tension and heart rate from ischemia. The biochemical findings were confirmed by histological investigations.\",\"PeriodicalId\":107168,\"journal\":{\"name\":\"The Internet Journal of Alternative Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2008-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"The Internet Journal of Alternative Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.5580/1a35\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Internet Journal of Alternative Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5580/1a35","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Protective effects of Semecarpus anacardium fruit extract against myocardial ischemia-reperfusion injury in rats
The purpose of the present study was to identify bioactivity in ethanolic extract of Semecarpus anacardium (EESA) fruits on experimentally induced myocardial damage in rats. The excised heart from previously treated rats was mounted and subjected to ischemia-reperfusion injury (IRI). The high dose of EESA significantly decreases endogenous biomarker enzymes such as LDH and CK-MB activities in perfusate and increases in heart tissue homogenate (HTH). Moreover, biological antioxidants viz., SOD and catalase activities were significantly increased in HTH. High dose of EESA were also found to provide significant recovery in developed tension and heart rate from ischemia. The biochemical findings were confirmed by histological investigations.
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