纯羟基磷灰石与铁取代羟基磷灰石烧结性能的比较研究

E. Kramer, M. Zilm, M. Wei
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引用次数: 15

摘要

羟基磷灰石(HA)是一种广泛应用于骨移植和组织工程的生物材料。透明质酸的晶体结构适合于各种各样的替代,从而可以定制材料属性。由于铁的磁性,它对HA中的离子取代很感兴趣。铁取代羟基磷灰石(FeHA)的合成和表征已经得到了广泛的研究,但相对于纯羟基磷灰石,FeHA材料的烧结性能研究较少。研究替代磷灰石的烧结行为提供了关于替代如何影响材料特性(如稳定性和整体机械性能)的信息,从而为替代材料的哪些应用提供了见解。在本研究中,合成了纯HA和FeHA,压制成球团,然后分别在900- 1300℃和600-1100℃的温度下烧结。该研究通过密度测量、力学测试、x射线衍射和电子显微镜彻底检查了两种材料的烧结行为。研究发现,FeHA的热稳定性明显低于纯HA,纯HA的分解开始于1200℃左右,而FeHA的分解开始于700℃。FeHA的机械强度也比纯HA低得多。将FeHA粉末浸泡在细胞培养基中,并以等量的HA粉末作为对照,进行了体外细胞培养研究,证实了FeHA是一种生物相容性材料。虽然FeHA不适合批量应用,但它是各种生物医学应用的潜在材料,包括药物输送、癌症热疗和骨组织工程复合材料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Comparative Study of the Sintering Behavior of Pure and Iron-Substituted Hydroxyapatite
Hydroxyapatite (HA) is a widely studied biomaterial for bone grafting and tissue engineering applications. The crystal structure of HA lends itself to a wide variety of substitutions, which allows for tailoring of material properties. Iron is of interest in ion substitution in HA due to its magnetic properties. The synthesis and characterization of iron-substituted hydroxyapatite (FeHA) have been widely studied, but there is a lack of studies on the sintering behaviors of FeHA materials compared to pure HA. Studying the sintering behavior of a substituted apatite provides information regarding how the substitution affects material characteristics such as stability and bulk mechanical properties, thereby providing insight into which applications are appropriate for the substituted material. In this study both pure HA and FeHA were synthesized, pressed into pellets, and then sintered at temperatures ranging from 900- 1300°C and 600-1100°C, respectively. The study thoroughly examined the comparative sintering behaviors of the two materials using density measurements, mechanical testing, X-ray diffraction, and electron microscopy. It was found that FeHA is considerably less thermally stable than pure HA, with decomposition beginning around 1200°C for pure HA samples, while at 700°C for the FeHA. The FeHA also had a much lower mechanical strength than that of the pure HA. An in vitro cell culture study was conducted by immersing FeHA powder in cell culture media, with HA powder at equivalent doses as a control, verified that FeHA is a biocompatible material. Although the FeHA would be unsuitable for bulk applications, it is a potential material for a variety of biomedical applications including drug delivery, cancer hyperthermia, and bone tissue engineering composites.
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