Effects of BMI changes over two years on lifestyle-related diseases

Objectives:Objectives: Increase in lifestyle-related diseases with high BMI has been shown in numerous epidemiological studies. The present study was a comparative investigation of the effects of changes in BMI over two years on representative lifestyle-related disease onset and normalization. Subjects: A total of 10,109 subjects (5,766 males and 4,343 females) who underwent annual health check-ups at Tokai University Hospital’s Health Screening Center in 2014 and 2016 were included in this study. Methods:Methods: Based on the WHO classification of obesity, and standard weight according to the Japan Society of Obesity, in 2014 the subjects were divided into four groups, by BMI, and in 2016 each group was divided into four groups, by BMI, to make 16 groups in total. The new-onset and normalization rates for hypertension, diabetes and dyslipidemia during this two year period were compared between the groups, with classification by sex. Results:Results: With both males and females, the hypertension new-onset rate increased with increasing BMI, but the new-onset rate also increased significantly in the groups showing BMI decrease. The diabetes new-onset rate increased with increasing BMI, but females who were slimmer than standard body type also showed increased normalization rate with BMI increase. With both males and females, the dyslipidemia new-onset rate increased with increasing BMI, and the normalization rate increased with decreasing BMI, but these relationships were weak with females. Conclusion:Conclusion: Changes in BMI are associated with new-onset and normalization rates, especially for dyslipidemia. Although hypertension and diabetes are associated with changes in BMI and new-onset and normalization rates, the involvement of other lifestyle-related factors must also be considered.