非胰岛素依赖型糖尿病患者和伴有或不伴有高脂血症的非糖尿病患者的脂蛋白颗粒大小异常。

Y Nakajo, A Tanaka, I Uchimura
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引用次数: 0

摘要

为了阐明糖尿病患者缺血性心脏病高发的机制,我们研究了脂蛋白的粒径,特别关注其结构异常。采用高效液相色谱法,用洗脱体积测定脂蛋白的粒径,洗脱体积与颗粒大小精确相关。在甘油三酯洗脱模式中,降脂糖尿病患者的低密度脂蛋白(LDL)粒径大于非糖尿病患者(p < 0.001)。对甘油三酯和胆固醇洗脱模式的检查显示,这个大的LDL是由大量的甘油三酯组成的。大LDL的这些特征与致动脉粥样硬化的中密度脂蛋白相似。通过甘油三酯的洗脱模式检测,正常血脂的糖尿病患者的高密度脂蛋白(HDL)的粒径大于非糖尿病对照组(p < 0.001)。甘油三酯和胆固醇洗脱模式的比较表明,正常血脂的糖尿病患者的大HDL也富含甘油三酯,据报道,甘油三酯可以抑制脂转运蛋白的活性。这些事实表明,不伴有高脂血症的脂质代谢紊乱产生了大量的LDL和HDL,这可能导致糖尿病患者在正常血脂的情况下缺血性心脏病的死亡率过高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Abnormal particle size of lipoprotein in non-insulin-dependent diabetics and nondiabetics with and without hyperlipidemia.

To clarify the mechanism of the high incidence of ischemic heart disease in the diabetics, we studied the particle size of the lipoprotein with particular attention to the structural abnormality. Using high performance liquid chromatography, the particle size of the lipoprotein was determined with elution volume, which was precisely correlated with the particle size. The particle size of low density lipoprotein (LDL) from the diabetics with normolipidemia is larger than that from the nondiabetics (p less than 0.001) in the elution pattern of triglyceride. The examination of the elution pattern of the triglyceride and cholesterol revealed that this large LDL was composed of a large amount of triglyceride. These characteristics of the large LDL resembled that of the atherogenic intermediate density lipoprotein. The particle size of high density lipoprotein (HDL) from the diabetics with normolipidemia was larger than that from the nondiabetic controls (p less than 0.001), detected by the elution pattern of triglyceride. The comparison of the triglyceride and cholesterol elution pattern indicated that also the large HDL in the diabetics with normolipidemia was rich with triglyceride, which was reported to inhibit the activity of the lipid transfer protein. These facts revealed that the disorder of the lipid metabolism not accompanied with hyperlipidemia produced the large LDL and HDL, which might lead to the excess mortality rate of the ischemic heart disease in the diabetics even with normolipidemia.

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