{"title":"异头苯基保护Man-Β(1,4)GlcNAc支架的简易合成:快速扩展寡糖分子多样性的构建块","authors":"J. I. Ayogu","doi":"10.2139/ssrn.3903182","DOIUrl":null,"url":null,"abstract":"A facile and efficient strategy for accessing Man-β(1,4)GlcNAc core was investigated. Anomeric benzyl protected acceptor derived from N-glycosamine hydrochloride was glycosylated with orthogonally protected thioglycoside to afford the gluc-β(1,4)GlcNAc scaffold which was epimerized via triflation to obtain the Man-β(1,4)GlcNAc derivative. The disaccharide Man-β(1,4)GlcNAc scaffold could be used as the basic building block for the divergent synthesis of various oligosaccharide structures for detailed biological activity investigation of glycans. The compounds were characterized by NMR, MS and Infra-red (IR) spectroscopy.","PeriodicalId":351264,"journal":{"name":"ChemRN: Natural Product Chemistry (Topic)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Facile Synthesis of Anomeric Benzyl Protected Man-Β(1,4)GlcNAc Scaffold as a Building Block for a Rapid Expansion of Oligosaccharide Molecular Diversity\",\"authors\":\"J. I. Ayogu\",\"doi\":\"10.2139/ssrn.3903182\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A facile and efficient strategy for accessing Man-β(1,4)GlcNAc core was investigated. Anomeric benzyl protected acceptor derived from N-glycosamine hydrochloride was glycosylated with orthogonally protected thioglycoside to afford the gluc-β(1,4)GlcNAc scaffold which was epimerized via triflation to obtain the Man-β(1,4)GlcNAc derivative. The disaccharide Man-β(1,4)GlcNAc scaffold could be used as the basic building block for the divergent synthesis of various oligosaccharide structures for detailed biological activity investigation of glycans. The compounds were characterized by NMR, MS and Infra-red (IR) spectroscopy.\",\"PeriodicalId\":351264,\"journal\":{\"name\":\"ChemRN: Natural Product Chemistry (Topic)\",\"volume\":\"1 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ChemRN: Natural Product Chemistry (Topic)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2139/ssrn.3903182\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemRN: Natural Product Chemistry (Topic)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2139/ssrn.3903182","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A Facile Synthesis of Anomeric Benzyl Protected Man-Β(1,4)GlcNAc Scaffold as a Building Block for a Rapid Expansion of Oligosaccharide Molecular Diversity
A facile and efficient strategy for accessing Man-β(1,4)GlcNAc core was investigated. Anomeric benzyl protected acceptor derived from N-glycosamine hydrochloride was glycosylated with orthogonally protected thioglycoside to afford the gluc-β(1,4)GlcNAc scaffold which was epimerized via triflation to obtain the Man-β(1,4)GlcNAc derivative. The disaccharide Man-β(1,4)GlcNAc scaffold could be used as the basic building block for the divergent synthesis of various oligosaccharide structures for detailed biological activity investigation of glycans. The compounds were characterized by NMR, MS and Infra-red (IR) spectroscopy.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
