L P Panchenko, O V Egorov, A S Raĭt, E M Ivanova, N V Amirkhanov, V F Zarytova, V V Vlasov, I G Skripal'
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引用次数: 0
摘要
研究了寡脱氧核糖核苷酸(oligodeoxyribonnucleotides, MPAO)的十甲酰酸酯和甲基膦酸酯类似物的烷基化衍生物与lailalai支原体PG-8、capricolum California Kid支原体、pneumoniae FH和植物致病菌株St. 118细胞的相互作用。结果表明，支原体细胞可吸附八烷基和十六烷基甲酰的MPAO，以及经非那嗪和胆固醇修饰的癸烷基甲酰3′端MPAO，并能穿透细胞内部。烷基化衍生物和MPAO与支原体细胞的结合效率取决于试剂的相互作用时间、反应混合物中的浓度和温度。
[The interaction of alkylating derivatives of oligodeoxyribonucleotides and their methylphosphonate analogs with Mycoplasma cells].
Alkylating derivatives of decathymidylates and methylphosphonate analogs of oligodeoxyribonucleotides (MPAO) were studied for their interaction with cells of Acholeplasma laidlawii PG-8, Mycoplasma capricolum California Kid, M. pneumoniae FH and phytopathogenic strain (St. 118). It is shown that MPAO of octa- and hexadecathymidylates as well as decathymidylates 3'-terminal modified by phenazine and cholesterol groupings are sorbed by mycoplasma cells and can penetrate inside the cells. Efficiency of binding of alkylating derivatives and MPAO with mycoplasma cells depends on interaction time of reagents, their concentration in the reaction mixture and temperature.
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