免疫调节表面活性剂蛋白D (SP-D)与麦芽糖配体结合的结构要求表征

B31. IMMUNE CELLS AND INFLAMMATORY PATHWAYS DRIVING LUNG INJURY AND INFECTION - VIEWS FROM THE BENCH Pub Date : 2022-05-01 DOI:10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2609

J. Madsen, Y. Ghrabigi, T. C. Hernandez, T. Greenhough, A. Shrive, H. Clark, Elizabeth, Garrett Anderson

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摘要

表面活性剂蛋白D (SP-D)是气道先天免疫系统的重要组成部分，负责清除入侵的病原体。SP-D是一种钙依赖性胶原凝集素，属于集合家族，利用其碳水化合物识别结构域与细菌和病毒等微生物的配体相互作用。了解人类SP-D的凝集素结构域如何与选定的糖类相互作用

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Characterisation of the Structural Requirements for the Immunomodulatory Surfactant Protein D (SP-D) to Bind to Maltose Based Ligands

Introduction: Surfactant protein D (SP-D) is an important part of the airway innate immune system, responsible for clearance of invading pathogens. As a calcium dependent collagenous lectin, SP-D belongs to the collectin family and uses its carbohydrate recognition domain to interact with ligands on microbes such as bacteria and viruses. An understanding of how the lectin domain of human SP-D interacts with selected saccharides

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B31. IMMUNE CELLS AND INFLAMMATORY PATHWAYS DRIVING LUNG INJURY AND INFECTION - VIEWS FROM THE BENCH

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