成人肾母细胞瘤:病例报告及文献复习

B. R. Bereza, Tariane Friedrich Foiato Maneti, Vitor Arce Ferreira Cathcart, Raimundo Romilton Leal do Rosário, P. Nunes, M. Luz
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引用次数: 1

摘要

肾母细胞瘤是一种极为罕见的成人肿瘤。它分别占成人和儿童肾肿瘤的95%和1%。成人和儿童的临床症状也不同。在成人中,症状通常是腹痛和血尿,另一方面,儿科患者经常出现无症状的腹部肿块。成人WT的推荐治疗遵循儿科患者的治疗方案。目前,成年WT患者的5年总生存率约为90%。采用系统化的多模式治疗,并根据目前的方案提出,使结果变得更加可靠,显著改善从不到30%提高到90%。然而,最近的评论表明,即使在接受相同的治疗方案时,成人的结果也比儿童差,并且根据组织学和肿瘤分期具有可比性。我们报告一个26岁的男性病人,他接受手术治疗肾实性肿块。病理报告显示为肾母细胞瘤。患者同时接受放线菌素和长春新碱辅助化疗。随访12个月后,患者无疾病迹象。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
WILMS TUMOR IN ADULTS: CASE REPORT AND REVIEW OF THE LITERATURE
Wilms Tumor (WT) is an extremely rare neoplasia in adults. It represents 95% and 1% of all renal tumors, in adults and children respectively. Clinical symptoms are also distinct between adults and children. In adults, symptoms are usually abdominal pain and hematuria, on the other hand, pediatric patients frequently present with an asymptomatic abdominal mass. The recommended treatment for WT in adults follows protocols established for pediatric patients. Currently, the 5-year overall survival rate for adults with WT is of approximately 90%. The adoption of multimodal therapy systematized, and proposed by current protocols, allowed the results to become much more robust, with a significant improvement from less than 30% to 90%. However, recent reviews suggest a worse outcome for adults when compared to children, even when submitted to the same treatment regimen, and comparable according to histology and tumor stage. We present a case of a 26 years-old male patient, who underwent surgery to treat a solid renal mass. Pathological report demonstrated a Wilms tumor. The patiente also received adjuvant chemotherapy with dactinomycin and vincristine. After 12 months follow-up, patient has no evidence of disease.
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