恐怖主义中的微生物制剂、生物标志物和公共卫生挑战

O. Orole, A. Chuku, K. Olawuyi, E. Mantu, Alexander J. Philips, C. Okoli
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引用次数: 0

摘要

生物恐怖主义制剂主要是具有对人类、动物和粮食作物造成爆炸性和致命伤害能力的微生物。这些微生物以气体、整个生物体或微生物次级代谢产物的形式传播。根据传播的难易程度和对生活人群的最终影响,将药剂分为三类。虽然大多数卫生机构有能力照顾病人和治疗疑似感染病例,但这些机构缺乏识别生物恐怖主义行为的基本手段。没有专门的诊断设备来确定致病生物或病原体。当恐怖分子使用生物制剂发动袭击时,缺乏如何应对的培训,会逐渐增加这类制剂的致命效果。在物种水平上识别微生物的分子技术虽然很有前途,但也很耗时,而在非洲的环境中,大多没有技术专长和管理这类设备的有利环境。作为紧急事项,非洲各国政府应营造一种氛围,使没有工作的人群得到就业,同时医院配备充足的设备,并培训卫生工作者在恐怖主义案件报告后立即采取的行动。这篇综述强调了促进早期应对生物恐怖主义所需的这些制剂和诊断工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microbial Agents in Terrorism, Biomarkers, and Public Health Challenges
Bioterrorism agents are mostly microorganisms with the capacity to deal explosive and lethal harm to humans, animals, and food crops. These microorganisms spread in the form of gases, whole organisms, or products of secondary metabolism of microorganisms. Classification of the agents is into three categories based on the ease of dissemination and end effects on a living population. While most health institutions are equipped to take care of sick people and treat suspected cases of infections, these institutions lack basic means of identifying bioterrorism acts. Special diagnostic equipment to identify causal organisms or agents is not available. Lack of training on what to do when terrorists strike using biological agents can cumulatively increase the lethal effects of such agents. Molecular techniques of identifying microorganisms to species level are as promising as they are time-consuming, while technical expertise and a conducive environment for managing such equipment are mostly not available in the African setting. The governments in Africa as a matter of urgency should provide an atmosphere where the teaming population of people without jobs are employed, while hospitals are adequately equipped, and training of health workers on what to do immediately after cases of terrorism are reported. The review highlights these agents and the diagnostic tools necessary to facilitate early response to bioterrorism.
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