[免疫调节药物对乙醇中毒大鼠肝脏溶酶体蛋白酶释放及活性的影响]。

E Skrzydlewska, L Chyczewski, K Worowski
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引用次数: 0

摘要

酒精(0.6 g/100 g体重)灌胃4周后,大鼠肝脏细胞质组分和匀浆中组织蛋白酶A和D活性升高。左旋咪唑和异丙苷++对胞浆组织蛋白酶A和D活性影响不大。Encorton降低了两种组织蛋白酶在细胞质组分中的活性,而没有降低它们在肝脏匀浆中的活性。左旋咪唑和异丙苷++引起乙醇中毒大鼠肝脏空泡变性和坏死灶的消退,以及糖原颗粒数量的增加,程度明显较轻。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Effect of immunomodulating drugs on the release and activities of lysosomal proteinases of the liver of rats with ethanol poisoning].

Increased activity of cathepsin A and D in the cytosol fraction and homogenate of the liver of rats intoxicated for 4 weeks with ethanol (0.6 g/100 g of the body weight) was found. The cytosol cathepsin A and D activities were unaffected under the influence of Levamisole and isoprinosine++. Encorton reduced the activity of both cathepsins in the cytosol fraction while it did not diminish their activities in the liver homogenates. Encorton, and to a markedly lesser degree, Levamisole and isoprinosine++ caused a regression of vacuolar degeneration and of necrotic lesions and an increase in the number of glycogen granules in the livers of ethanol-intoxicated rats.

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