{"title":"[免疫调节药物对乙醇中毒大鼠肝脏溶酶体蛋白酶释放及活性的影响]。","authors":"E Skrzydlewska, L Chyczewski, K Worowski","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Increased activity of cathepsin A and D in the cytosol fraction and homogenate of the liver of rats intoxicated for 4 weeks with ethanol (0.6 g/100 g of the body weight) was found. The cytosol cathepsin A and D activities were unaffected under the influence of Levamisole and isoprinosine++. Encorton reduced the activity of both cathepsins in the cytosol fraction while it did not diminish their activities in the liver homogenates. Encorton, and to a markedly lesser degree, Levamisole and isoprinosine++ caused a regression of vacuolar degeneration and of necrotic lesions and an increase in the number of glycogen granules in the livers of ethanol-intoxicated rats.</p>","PeriodicalId":77367,"journal":{"name":"Roczniki Akademii Medycznej w Bialymstoku = Annales Academiae Medicae Bialostocensis","volume":"35-36 ","pages":"163-75"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Effect of immunomodulating drugs on the release and activities of lysosomal proteinases of the liver of rats with ethanol poisoning].\",\"authors\":\"E Skrzydlewska, L Chyczewski, K Worowski\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Increased activity of cathepsin A and D in the cytosol fraction and homogenate of the liver of rats intoxicated for 4 weeks with ethanol (0.6 g/100 g of the body weight) was found. The cytosol cathepsin A and D activities were unaffected under the influence of Levamisole and isoprinosine++. Encorton reduced the activity of both cathepsins in the cytosol fraction while it did not diminish their activities in the liver homogenates. Encorton, and to a markedly lesser degree, Levamisole and isoprinosine++ caused a regression of vacuolar degeneration and of necrotic lesions and an increase in the number of glycogen granules in the livers of ethanol-intoxicated rats.</p>\",\"PeriodicalId\":77367,\"journal\":{\"name\":\"Roczniki Akademii Medycznej w Bialymstoku = Annales Academiae Medicae Bialostocensis\",\"volume\":\"35-36 \",\"pages\":\"163-75\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1990-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Roczniki Akademii Medycznej w Bialymstoku = Annales Academiae Medicae Bialostocensis\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Roczniki Akademii Medycznej w Bialymstoku = Annales Academiae Medicae Bialostocensis","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Effect of immunomodulating drugs on the release and activities of lysosomal proteinases of the liver of rats with ethanol poisoning].
Increased activity of cathepsin A and D in the cytosol fraction and homogenate of the liver of rats intoxicated for 4 weeks with ethanol (0.6 g/100 g of the body weight) was found. The cytosol cathepsin A and D activities were unaffected under the influence of Levamisole and isoprinosine++. Encorton reduced the activity of both cathepsins in the cytosol fraction while it did not diminish their activities in the liver homogenates. Encorton, and to a markedly lesser degree, Levamisole and isoprinosine++ caused a regression of vacuolar degeneration and of necrotic lesions and an increase in the number of glycogen granules in the livers of ethanol-intoxicated rats.