kit受体及其配体钢铁因子作为造血调节因子。

IF 3.5 Q1 DENTISTRY, ORAL SURGERY & MEDICINE
H E Broxmeyer, R Maze, K Miyazawa, C Carow, P C Hendrie, S Cooper, G Hangoc, S Vadhan-Raj, L Lu
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引用次数: 0

摘要

携带显性白色斑点位点(W)或显性钢位点(Sl)突变的小鼠品系贫血,在色素沉着和配子发生方面表现出缺陷。在W突变体中,贫血是由于造血干细胞的缺乏,而在Sl突变体中,是由于骨髓中支持基质细胞的缺乏。W位点编码c-kit原癌基因产物,一种具有蛋白酪氨酸激酶活性的细胞表面受体,Sl位点编码其配体,一种造血细胞因子,被称为钢铁因子(SLF)、肥大细胞生长因子、干细胞因子和Kit配体。SLF能与多种细胞因子协同作用,在体外刺激造血祖细胞生长,在体内刺激动物血细胞生成。本文综述了SLF的生物学活性,重点介绍了其对造血干细胞和祖细胞的作用。我们还讨论了参与SLF触发信号转导的分子的现有知识,并推测SLF在人类疾病中的潜在治疗应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The kit receptor and its ligand, steel factor, as regulators of hemopoiesis.

Mouse strains carrying mutations at the Dominant White Spotting (W) locus or the Steel (Sl) locus are anemic and display defects in pigmentation and gametogenesis. In W mutants the anemia is due to a deficiency of hemopoietic stem cells and, in Sl mutants, to a deficiency of supporting stromal cells in the bone marrow. The W locus encodes the c-kit proto-oncogene product, a cell surface receptor with protein-tyrosine kinase activity, and the Sl locus encodes its ligand, a hemopoietic cytokine known variously as Steel factor (SLF), mast cell growth factor, stem cell factor, and Kit ligand. SLF can synergize with a number of other cytokines to stimulate growth of hemopoietic progenitors in vitro and stimulates blood cell production in vivo in animals. Here we review the biological activities of SLF, with particular emphasis on its effects on hemopoietic stem and progenitor cells. We also discuss present knowledge of the molecules involved in SLF-triggered signal transduction, and speculate on potential therapeutic applications for SLF in human disease.

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