ASSESSMENT OF HORMONAL STATUS WITH AN ESTABLISHED MOLECULAR-BIOLOGICAL PROFILE OF PATIENTS WITH BREAST CANCER OF DIFFERENT REPRODUCTIVE PERIOD

In the course of the study, it was found that the luminal A subtype in patients with breast cancer is associated in 100% of cases with increased blood levels of estradiol, progesterone, and prolactin. In the postmenopausal period, the luminal B (Her-2-positive) subtype is associated with a 100% increase in the concentration of the hormones estradiol and progesterone. In patients with preserved ovarian-menstrual function, luminal B (Her-2-positive) subtype in 37.5% of cases is associated with increased estradiol content. Luminal B (Her-2-negative) subtype is associated with increased blood levels of estradiol, progesterone, and prolactin in 100% of patients. The Her-2 / neu-positive subtype is associated with decreased serum estradiol levels in 33% of patients and decreased progesterone levels in 83% of patients. In patients with a triple-negative subtype, an increased content of estradiol and progesterone in the blood was diagnosed in 100% of patients.