帕金森病:用可穿戴设备抑制震颤

Samuel E. Winston, Riley C. Dehmer, T. Doughty
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摘要

帕金森氏症(PD)是一种神经退行性疾病,在美国影响着近100万人。手部震颤是帕金森病的一个众所周知的症状,它会导致焦虑、沮丧和营养不良。虽然无法治愈,但有几种方法试图治疗这些症状。许多是侵入性的,包括使用药物和手术。非侵入性技术通常很麻烦,并且不能解决在公共场合经历地震的明显性质。这项研究的动机是由以前的研究[2]建立的设计标准,目标是经济实惠的纯机械解决方案。在这两种情况下,人类受试者的测试结果与有效减少震颤的实验室测试结果一致。可穿戴设备的扩展使用户能够握住或处理任何物体,或者没有物体,同时显著减少震颤。两个独立的可穿戴设备进行了有效性测试,同时模拟用户“拿着”两个不同的物体来模拟不同的应用程序。人类手的生物力学建模为可调机械手颤系统的开发提供了信息。采用装置模型和手-装置界面模型对耦合系统的动态响应进行了仿真。每个装置都固定在机械手震颤系统上,并在典型震颤频率范围内收集谐波刺激和响应数据。结果证明了两种设计在减少与震颤相关的振荡方面的通用性。定义了减少比(RoR)来比较有和没有装置的手震颤系统的震颤幅度。两种设计都被认为对每个对象有效,设备a的最大RoR为28.09,设备B的最大RoR为99.32。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Parkinsons Disease: Tremor Suppression With Wearable Device
Parkinson’s Disease (PD) is a neurodegenerative disorder that affects nearly a million people in the United States. Hand tremors are a well-known symptom associated with PD and result in anxiety, frustration, and malnutrition. While there is no cure, several approaches attempt to treat the symptoms. Many are invasive, including the use of pharmaceuticals and surgery [1]. Noninvasive technologies are often cumbersome and do not address the conspicuous nature experiencing tremors in public. This study is motivated by design criteria established from previous research [2], with a goal of an affordable, purely mechanical solution. In both cases, human subject testing echoed lab tests in effective tremor reduction. The extension to a wearable device gives the user the ability to hold or handle any object, or no object, with a significant reduction in tremor. Two separate wearable devices were tested for effectiveness while the simulated user ‘held’ two different objects to simulate different applications. Biomechanical modeling of the human hand informed the development of an adjustable mechanical hand-tremor system for testing. Models of the devices and the hand-device interface were used to simulate the dynamic response of the coupled systems. Each device was secured to the mechanical hand-tremor system and harmonic stimulus and response data was collected over the range of typical tremor frequencies. The results demonstrate the versatility of both designs for reducing the oscillations associated with tremors. The Ratio of Reduction (RoR) was defined to compare the tremor amplitude of the hand-tremor system with and without the device. Both designs were considered effective for each object with a max RoR of 28.09 for Device A and a max RoR of 99.32 for Device B.
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