以病变为基础的耳、唇、眼睑放射治疗皮肤癌

Anthony Tanous, D. Tighe, J. Bartley, G. Gottschalk, Tanya Gilmour, N. Lotz, G. Fogarty
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引用次数: 1

摘要

目的:本研究是对澳大利亚悉尼的耳、眼睑和唇部皮肤癌放疗(RT)的回顾性审计。还评估了在特定时期内转诊到三级放射肿瘤学服务的增长情况。材料与方法:回顾2007年1月1日至2020年4月30日期间接受外耳、眼睑或唇部RT的患者记录。记录患者、肿瘤、治疗和预后因素。结果:147例平均年龄为73岁(范围:33-96岁)的患者被确定为符合纳入条件。165个病灶得到治疗,18例患者出现多重治疗事件。在所有治疗的病变中,基底细胞癌81例(49.2%),皮肤鳞状细胞癌65例(39.4%),恶性lentigo (LM) 7例(4.2%),皮脂腺癌2例(1.2%),默克尔细胞癌2例(1.2%),鲍文氏病4例(2.4%),光化变2例(1.2%),瘢痕瘤2例(1.2%)。平均随访时间为42周。108例患者接受了明确的放疗,即作为初次治疗而非术后治疗。3 ~ 61个月内BCC复发5例,cSCC复发3例。6例(75%)成功打捞。26例患者出现晚期副作用,其中美容效果异常最为常见(6/26;23.1%)。结论:基于病灶的耳、眼睑、唇部皮肤癌放射治疗是安全有效的。明确的放射治疗可能比手术更可取,特别是当组织丢失可能导致功能和美容结果不佳时。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lesion-based radiotherapy of the ears, lips and eyelids for skin cancer
Purpose: This study is a retrospective audit of radiotherapy (RT) for skin cancer of the ear, eyelid, and lip in Sydney, Australia. The growth of referrals to a tertiary radiation oncology service over a specific time period were also assessed. Materials and Methods: The records of patients who received RT to the external ear, eyelid or lip between January 1 2007 and April 30 2020 were reviewed. Patient, tumour, treatment and outcome factors were recorded. Results: 147 patients with a mean age of 73 years (range: 33-96) were identified as eligible for inclusion. 165 lesions were treated and 18 patients had multiple treatment events. Of all the treated lesions, 81 were basal cell carcinoma (49.2%), 65 cutaneous squamous cell carcinoma (39.4%), 7 lentigo maligna (LM) (4.2%), 2 sebaceous carcinoma (1.2%), 2 merkel cell carcinoma (1.2%), 4 Bowen’s disease (2.4%), 2 actinic change (1.2%) and 2 keloid treatments (1.2%). The mean follow-up was 42 weeks. Definitive RT, that is, RT given as primary treatment rather than post operatively, was given in 108 cases. There were five cases of BCC recurrence and three cases of cSCC recurrence within 3 - 61 months. These were successfully salvaged in six cases (75%). Late side effects were seen in 26 patients with abnormal cosmetic results being the most common late effect (6/26; 23.1%). Conclusion: Lesion-based RT for skin cancer of the ear, eyelid, and lip can be delivered safely and is effective. Definitive RT may be preferable to surgery especially when tissue loss may lead to poor functional and cosmetic outcomes.
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