用于(生物分子)力传感的压阻式探针

The 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems Pub Date : 2013-04-07 DOI:10.1109/NEMS.2013.6559917

J. Bausells, G. Tosolini, Y. Birhane, F. Pérez-Murano

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引用次数: 0

摘要

我们已经开发了自传感压阻微悬臂，优化了(生物分子)力的测量。典型尺寸为长250 μm，宽8 ~ 20 μm，厚450 nm，弹簧常数约为1 mN/m。这些器件已经在硅片上进行了机电测试，根据悬臂尺寸的不同，在35到130 pN之间的空气中显示出良好的力分辨率。我们还测试了悬臂梁在液体环境中的机电性能，结果表明，与在空气中的响应相比，该装置的力灵敏度和噪声特性都没有明显下降。这为悬臂梁在生物分子单分子力谱中的应用开辟了道路。

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Piezoresistive probes for (biomolecular) force sensing

We have developed self-sensing piezoresistive microcantilevers optimized for the measurement of (biomolecular) forces. Typical dimensions are 250 μm in length, 8-20 μm in width and 450 nm in thickness, with spring constants of about 1 mN/m. The devices have been electromechanically tested on wafer and show good force resolutions in air between 35 and 130 pN depending on the cantilever dimensions. We have also tested the electromechanical behavior of the cantilevers in liquid environment and we show that both the force sensitivity and the noise characteristics of the devices are not noticeably degraded as compared with their response in air. This opens the way to the use of the cantilevers in single molecule force spectroscopy of biomolecules.

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The 8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems

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