新生儿癫痫发作的临床及生化特征研究

Dr. B Adithya Nikhileshwar, Dhaval Bhatt, Dr. Harshida Vagadoda, Dr. Yesha Prajapati
{"title":"新生儿癫痫发作的临床及生化特征研究","authors":"Dr. B Adithya Nikhileshwar, Dhaval Bhatt, Dr. Harshida Vagadoda, Dr. Yesha Prajapati","doi":"10.33545/26643685.2023.v6.i1a.190","DOIUrl":null,"url":null,"abstract":"Introduction: Neonatal Seizure is defined as a paroxysmal involuntary disturbance of cerebral function. Neonatal seizures are a common problem. Common etiology of neonatal seizures is brain disorders, hypoxic-ischemic encephalopathy, central nervous system (CNS) infections, CNS bleeds, and structural anomalies of the brain or secondary to metabolic problems, for example, hypoglycemia, hyponatremia, and other electrolyte disturbances. Objective: To study Clinical and Biochemical abnormalities associated with neonatal seizures. Material and Methods: An observational study was conducted in ninety newborns with seizures admitted in neonatal intensive care unit (NICU). After taking a complete history and appropriate physical examination, blood sample was collected for detecting metabolic abnormalities before instituting specific therapy. Results: Total ninety neonates presented with seizures were enrolled in this study. Among them, male was 52 (57.78%), and female was 38 (42.22%). In present study, majority of neonates 30% had the onset of seizures within 24 hr. In ninety neonates, the number of neonates with subtle seizures was 62 (68.89%), tonic seizure was 11 (12.22%), and clonic was 10 (11.11%).In ninety neonates, hypoglycemia was reported in 32.22% of neonates, followed by birth asphyxia 25.56%, hypocalcemia in 24.44% neonates, hyponatremia in 13.33% of neonates, hypomagnesemia in 4.44% of neonates. Conclusion: Early identification and management of biochemical abnormalities are essential for satisfactory long-term outcome. The common metabolic causes for neonatal seizures in India include hypoglycemia, hypocalcemia, birth asphyxia, hyponatremia, and hypomagnesemia.","PeriodicalId":144032,"journal":{"name":"International Journal of Paediatrics and Geriatrics","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Study of clinical and biochemical profile of neonatal seizures\",\"authors\":\"Dr. B Adithya Nikhileshwar, Dhaval Bhatt, Dr. Harshida Vagadoda, Dr. Yesha Prajapati\",\"doi\":\"10.33545/26643685.2023.v6.i1a.190\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: Neonatal Seizure is defined as a paroxysmal involuntary disturbance of cerebral function. Neonatal seizures are a common problem. Common etiology of neonatal seizures is brain disorders, hypoxic-ischemic encephalopathy, central nervous system (CNS) infections, CNS bleeds, and structural anomalies of the brain or secondary to metabolic problems, for example, hypoglycemia, hyponatremia, and other electrolyte disturbances. Objective: To study Clinical and Biochemical abnormalities associated with neonatal seizures. Material and Methods: An observational study was conducted in ninety newborns with seizures admitted in neonatal intensive care unit (NICU). After taking a complete history and appropriate physical examination, blood sample was collected for detecting metabolic abnormalities before instituting specific therapy. Results: Total ninety neonates presented with seizures were enrolled in this study. Among them, male was 52 (57.78%), and female was 38 (42.22%). In present study, majority of neonates 30% had the onset of seizures within 24 hr. In ninety neonates, the number of neonates with subtle seizures was 62 (68.89%), tonic seizure was 11 (12.22%), and clonic was 10 (11.11%).In ninety neonates, hypoglycemia was reported in 32.22% of neonates, followed by birth asphyxia 25.56%, hypocalcemia in 24.44% neonates, hyponatremia in 13.33% of neonates, hypomagnesemia in 4.44% of neonates. Conclusion: Early identification and management of biochemical abnormalities are essential for satisfactory long-term outcome. The common metabolic causes for neonatal seizures in India include hypoglycemia, hypocalcemia, birth asphyxia, hyponatremia, and hypomagnesemia.\",\"PeriodicalId\":144032,\"journal\":{\"name\":\"International Journal of Paediatrics and Geriatrics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Paediatrics and Geriatrics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33545/26643685.2023.v6.i1a.190\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Paediatrics and Geriatrics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33545/26643685.2023.v6.i1a.190","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

简介:新生儿癫痫发作被定义为一种阵发性不自主的大脑功能紊乱。新生儿癫痫是一个常见的问题。新生儿癫痫发作的常见病因是脑部疾病、缺氧缺血性脑病、中枢神经系统(CNS)感染、中枢神经系统出血、脑结构异常或继发于代谢问题,如低血糖、低钠血症和其他电解质紊乱。目的:探讨新生儿癫痫发作的临床及生化异常。材料和方法:对90例新生儿重症监护病房(NICU)的癫痫发作新生儿进行观察性研究。在进行完整的病史和适当的体格检查后,采血检测代谢异常,然后进行特异性治疗。结果:共有90名出现癫痫发作的新生儿被纳入本研究。其中,男性52人(57.78%),女性38人(42.22%)。在本研究中,30%的新生儿在24小时内发作。90例新生儿中,轻度发作62例(68.89%),强直性发作11例(12.22%),阵挛性发作10例(11.11%)。90例新生儿中,低血糖发生率为32.22%,其次为出生窒息25.56%,低钙发生率为24.44%,低钠血症发生率为13.33%,低镁血症发生率为4.44%。结论:早期发现和处理生化异常对获得满意的远期疗效至关重要。印度新生儿癫痫发作的常见代谢性原因包括低血糖、低钙血症、出生窒息、低钠血症和低镁血症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study of clinical and biochemical profile of neonatal seizures
Introduction: Neonatal Seizure is defined as a paroxysmal involuntary disturbance of cerebral function. Neonatal seizures are a common problem. Common etiology of neonatal seizures is brain disorders, hypoxic-ischemic encephalopathy, central nervous system (CNS) infections, CNS bleeds, and structural anomalies of the brain or secondary to metabolic problems, for example, hypoglycemia, hyponatremia, and other electrolyte disturbances. Objective: To study Clinical and Biochemical abnormalities associated with neonatal seizures. Material and Methods: An observational study was conducted in ninety newborns with seizures admitted in neonatal intensive care unit (NICU). After taking a complete history and appropriate physical examination, blood sample was collected for detecting metabolic abnormalities before instituting specific therapy. Results: Total ninety neonates presented with seizures were enrolled in this study. Among them, male was 52 (57.78%), and female was 38 (42.22%). In present study, majority of neonates 30% had the onset of seizures within 24 hr. In ninety neonates, the number of neonates with subtle seizures was 62 (68.89%), tonic seizure was 11 (12.22%), and clonic was 10 (11.11%).In ninety neonates, hypoglycemia was reported in 32.22% of neonates, followed by birth asphyxia 25.56%, hypocalcemia in 24.44% neonates, hyponatremia in 13.33% of neonates, hypomagnesemia in 4.44% of neonates. Conclusion: Early identification and management of biochemical abnormalities are essential for satisfactory long-term outcome. The common metabolic causes for neonatal seizures in India include hypoglycemia, hypocalcemia, birth asphyxia, hyponatremia, and hypomagnesemia.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信