哺乳动物中枢神经系统P物质受体。

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology Pub Date : 1991-01-01

T Segawa, Y Nakata

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引用次数: 0

摘要

1. 新鲜制备的大鼠脑膜中存在多种不同的P物质受体亲和状态或位点。2. P物质受体可能与胰岛激活蛋白(百日咳毒素)敏感的gtp结合蛋白偶联。3.P物质受体可能以相反的方式调节Mg2+和Na+。4. 除了gtp结合蛋白外，一些重要的因子似乎也参与了SP的结合活性。5. SP结合位点的表观分子量约为46,000 Da。

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Substance P receptors in mammalian central nervous system.

1. Multiple distinct affinity states or sites of substance P (SP) receptors exist in freshly-prepared rat brain membranes. 2. Substance P receptors may couple with islet-activating protein (pertussis toxin) sensitive GTP-binding protein(s). 3. Substance P receptors may be regulated Mg2+ and Na+ in an opposite manner. 4. Some important factor(s), in addition to GTP-binding protein, appear to be involved in SP binding activity. 5. An apparent molecular weight of the SP binding site is approximately 46,000 Da.

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Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology

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