角蛋白对K3/K12在鸡和兔胚胎和成人角膜上皮分化过程中的表现

Cell differentiation and development : the official journal of the International Society of Developmental Biologists Pub Date : 1990-12-01 DOI:10.1016/0922-3371(90)90103-4

Catherine Chaloin-Dufau , Danielle Dhouailly , Tung-Tien Sun

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引用次数: 93

摘要

利用单克隆抗体结合电泳分析，研究了角膜上皮细胞分化过程中K3/K12角蛋白对的序列表达。在鸡胚中，K12在第12天出现，而K3至少从第11天开始出现。相比之下，在兔胚胎中，K12(17天)的表达先于K3(21天)。在成年兔中，K3在部分边缘不表达K12。因此，在角膜型角蛋白对中，根据发育阶段或物种，酸性或碱性伴侣首先出现。

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Appearance of the keratin pair K3/K12 during embryonic and adult corneal epithelial differentiation in the chick and in the rabbit

Sequential expression of the K3/K12 keratin pair was studied during epithelial corneal differentiation, using monoclonal antibodies coupled with electrophoretic analysis. In the chick embryo, K12 appears on day 12, while K3 is present at least from day 11. By contrast, in the rabbit embryo, the expression of K12 (at 17 days) precedes that of K3 (at 21 days). In the adult rabbit, K3 is expressed without K12 in part of the limbus. Thus, within the corneal-type keratin pair, either the acidic or the basic partner appears first, according to the developmental stage or the species.

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Cell differentiation and development : the official journal of the International Society of Developmental Biologists

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