口服辅酶q10对尼古丁暴露wistar大鼠随机皮瓣活力的影响

Wilma Agustina, A. S. Budi, S. Rizaliyana
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摘要

简介:尼古丁被认为是导致皮瓣受损的原因。服用抗氧化剂可以消除这种影响,其中最有前途的抗氧化剂是辅酶Q10。本研究旨在发现口服辅酶Q10对尼古丁暴露的wistar大鼠随机皮瓣活力的影响。方法:褐家鼠27只,随机分为3组。第一组不给予尼古丁,另外两组连续4周雾化尼古丁,随机皮瓣处理。第三组给予辅酶Q10 7 d。然后,对皮瓣样本进行标准的组织病理学染色和血管内皮生长因子(VEGF)测定,以检测新生血管的程度和VEGF细胞的表达。结果:ⅰ组平均毛细血管数为5.33±1.323根,ⅱ组为5.89±0.782根,ⅲ组为7.78±2.587根。I组与II组VEGF表达差异无统计学意义(p = 0.317, 95% CI)。然而,I组和III组、II组和III组的VEGF强度差异有统计学意义(p = 0.009, 95% CI) (p = 0.011, 95% CI)。因此,与其他两组相比,辅酶Q10对受试者的强度更强。结论:辅酶Q10通过增加毛细血管数量和VEGF表达来提高随机皮瓣的存活率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
THE EFFECT OF ORALLY ADMINISTERED COENZYME Q10 ON THE VIABILITY OF RANDOM SKIN FLAP IN NICOTINE EXPOSED WISTAR RATS
Introduction : Nicotine was assumed to be the cause of compromised flap. The administration of antioxidants can eliminate such effect, and one of the most promising antioxidants is Coenzyme Q10. The research aims to find the effect of orally administered Coenzyme Q10 on the viability of random skin flaps in nicotine-exposed wistar rats. Method : Twenty-seven white rats (Rattus norvegicus) were assigned in three groups. The first group received no nicotine, while the other two groups were nebulized with nicotine for 4 consecutive weeks, and treated as random skin flaps. In third group, Coenzyme Q10 was administered for 7 days. Then, a standard histopathological staining and vascular endothelial growth factor (VEGF) measurement were performed on flap sample to examine the extent of neovascularization and VEGF cell expression. Result : The average number of capillaries in group I was 5.33 ± 1.323, in group II was 5.89 ± 0.782, and in group III was 7.78 ± 2.587. There was no significant difference (p = 0.317, 95% CI) in groups I and II of VEGF expression. However, significant differences were found in the intensity of VEGF (p = 0.009, 95% CI) in groups I and group III, and in groups II and group III (p = 0.011, 95% CI). Thus, the intensity was stronger on the subject with coenzyme Q10 compared with the other two groups. Conclusion: Coenzyme Q10 increases the viability of random flaps by increasing the number of capillaries and VEGF expression.
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