Pressure Gradient Control Strategies Based on Disturbance Rejection for Typical Pharmaceutical Cleanrooms

Keeping pressure gradient is an excellent approach to prevent the reveal of airflow direction and cross infection in manufacturing circumstances of pharmaceutical cleanrooms, thus how to keep cleanroom’s pressure is critical. In the paper, we study a positive pressure pharmaceutical cleanroom system which is composed by a cleanroom and an airlock. We divide the system’s disturbances into step disturbance, ramp disturbance and sine wave disturbance. We design its pressure gradient control strategies, including CAV control, PID control and active-disturbance-rejection-control. We build the system’s model and make simulations based on Matlab/Simulink software platform. Results show that active-disturbance-rejection-control algorithm has good capabilities for shorter responding time and lower overshot of the pressure gradient. The results reveal that active-disturbance-rejection-control method has good control performances in responding time, accuracy and disturbance rejection.