测定透析出水不同波长紫外线吸收对血液透析过程溶质动力学的影响

2020 IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering (EIConRus) Pub Date : 2020-01-01 DOI:10.1109/EIConRus49466.2020.9039273

O. Stepanova, G. Konoplev, Zemchenkov Gennady, A. Kuznetsov, A. Frorip

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引用次数: 0

摘要

采用无创在线血透监测的光电光谱传感器，分析了血液透析过程中紫外吸收溶质的消除动力学;深紫外led被用作波长285 nm(与尿酸相关)和365 nm(与晚期糖基化终产物相关)的紫外辐射源。测量了一组患者在血液透析治疗过程中流出透析液紫外线吸收的时间曲线;传感器被连接到一台透析机的插座上。根据双池动力学模型，用两个指数函数和拟合所得曲线。分析了不同工作波长下模型参数(主要是室间传递时间常数)的变化规律。

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Analysis of Solute Kinetics During Hemodialysis Treatment by Measuring the UV Absorption of Effluent Dialysate at Different Wavelengths

The elimination kinetics of UV absorbing solutes during hemodialysis treatment was analyzed by means of the optoelectronic spectral sensor for non-invasive online hemodialysis monitoring; deep UV LEDs were used as the source of UV radiation at the wavelengths 285 nm (associated with uric acid) and 365 nm (associated with advanced glycation end products). The time profiles of effluent dialysate UV absorption in the course of hemodialysis treatment sessions were measured for a group of patients; the sensor was connected to the outlet of a dialysis machine. The acquired curves were assessed and fitted by the sum of two exponential functions according to the doublepool kinetic model. Variations between the parameters of the model (mainly time constants of intercompartment transfer) for different working wavelengths were analyzed.

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来源期刊

2020 IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering (EIConRus)

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