心肌三维传播的计算机模拟。纤维内部旋转和电阻不均匀性的影响

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society Volume 13: 1991 Pub Date : 1991-10-31 DOI:10.1109/IEMBS.1991.684140

A. Pollard

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引用次数: 4

摘要

对动作电位在心肌中的传播进行了三维膜模拟。具体来说，研究了纤维轴的内部旋转和电阻不均匀性对激活模式的影响。建立了两个模型，每个模型中有28,977个微观元素排列在矩形平行体中。模拟采用非线性Ebihara和Johnson膜方程计算快速钠电流。构建的模型具有心室心肌组织学特征。所有模拟都是在犹他州超级计算机研究所的IBM 3090上进行的。

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Computer Simulations Of Three-dimensional Propagation In Ventricular Myocardium. The Effects Of Intramural Fiber Rotation And Resistive Inhomogeneity

Three-dimensional membrane-based simulations of action potential propagation in ventricular myocardium were performed. Specifically, the effects of the intramural rotation of the fiber axes and resistive inhomogeneity on the pattern of activation were examined. Two models were built, with 28,977 microscopic elements arranged in rectangular parallelpipeds in each model. Simulations used the nonlinear Ebihara and Johnson membrane equations for the fast sodium current. Constructed models had histologic features of ventricular myocardium. All simulations were performed on an IBM 3090 at the Utah Supercomputer Institute.

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Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society Volume 13: 1991

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