DNA变性转变的动力学

EPL (Europhysics Letters) Pub Date : 2012-04-25 DOI:10.1209/0295-5075/98/48004

T. S. van Erp, M. Peyrard

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引用次数: 13

摘要

使用Peyrard-Bishop-Dauxois模型研究了DNA变性的动力学。在变性温度以下，双链聚合物的变性速率随长度的变化呈指数递减。在Tc以上，速率显示最小值，但随后随着长度的增加而增加。我们还考察了顺序和溶剂摩擦的影响。弱碱基对和强碱基对数目相同的分子，根据碱基对的顺序不同，其打开率也会有显著差异。

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The dynamics of the DNA denaturation transition

The dynamics of the DNA denaturation is studied using the Peyrard-Bishop-Dauxois model. The denaturation rate of double stranded polymers decreases exponentially as a function of length below the denaturation temperature. Above Tc, the rate shows a minimum, but then increases as a function of length. We also examine the influence of sequence and solvent friction. Molecules having the same number of weak and strong base-pairs can have significantly different opening rates depending on the order of base-pairs.

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EPL (Europhysics Letters)

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