创建蛋白质本体资源

A. Sidhu, T. Dillon, E. Chang
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引用次数: 5

摘要

目前,蛋白质数据集成方法将数据源视为数据存储库,而不是应用程序;这反过来又可能包含与其他数据源的复杂交互。目前的方法没有提供通用的映射蛋白质数据表示方法,描绘它所描述的数据中的相互作用,也没有提供连接现有数据的方法。提出的蛋白质本体显示了蛋白质组学数据中存在的层次和关系的价值。蛋白质本体的创建提供了对不同类型数据的理解,如:(1)蛋白质入口细节,(2)蛋白质的3D结构表示,(3)蛋白质中保守的结构褶皱和结构域,(4)基于蛋白质的生理和病理功能创建的功能域和家族,以及(5)影响蛋白质最终稳定分子结构的各种约束,如遗传缺陷和细胞化学性质。蛋白质本体描述了对蛋白质复杂机制和蛋白质组学过程感兴趣的概念。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Creating a protein ontology resource
Protein Data Integration approaches at the moment considers data sources as data repositories, but not as applications; which in turn may embody complex interactions with other data sources. Current approaches do not provide methods both for generic mapping protein data representation, depicting interactions in data it describes and for interfacing existing data. The proposed Protein Ontology shows the value of hierarchy and relationships present in proteomics data. The creation of a Protein Ontology provides understanding of diverse types of data like: (1) Protein Entry Details, (2) 3D Structural Representations of Proteins, (3) Structural Folds and domains conserved in proteins, (4) Functional Domains and Families created based on Physiological and Pathological Functions of Proteins, and (5) Various Constraints like Genetic Defects and Chemical Properties of Cell that affect Final Stable Molecular Structure of Protein. Protein Ontology describes the concepts of interest in protein complex mechanisms and proteomics process.
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