维生素D与糖尿病、流行病和衰老。有什么新鲜事吗?

Monique Resende Costa Machado, Saint Clair Gomes Junior, Lizanka Paola Figueiredo Marinheiro
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引用次数: 7

摘要

2型糖尿病一直是一个令人关注的公共卫生问题,因此其诊断和治疗在临床实践中一直存在延误。尽管在过去的几十年里,由于更好的病理生理学理解和在不同阶段和水平上起作用的药物的发展,糖尿病的治疗得到了改善,但新的糖尿病病例的增加要求了解最新的治疗靶点,以预防和治疗这种疾病。交叉和纵向研究积累的证据表明维生素D可能参与糖尿病的病理生理。然而,这些结果是基于少量样本的临床研究,并没有考虑到绝经后妇女等特定人群,因为没有确定需要提供的维生素D剂量。早期诊断、治疗和缓解影响生活质量的紊乱和疾病在面对长期老龄化时极为有用。我们提出了维生素D如何参与糖尿病病理生理和一些研究结果的实现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vitamina D e diabetes mellitus, suas epidemias e o envelhecimento. O que há de novo?

Type 2 diabetes has been an of public health concern and therefore has its diagnosis and treatment delayed in clinical practice. Although, its treatment has improved in the last decades by better pathophysiology understanding and development of medicines that act in different phases and levels, the increase of new cases of diabetes claim for knowledge about newest terapheutics targets in order to prevent and treat this disease. Accumulated evidences from crossover and longitudinal studies suggested a potencial participation of Vitamin D in diabetes pathophysiology. However, the results are based on clinical studies with a few sample and do not consider specifical populations like post menopausal women as did not determine dose of vitamin D that need to be offered. Early diagnosis, treatment and relieve of disorders and diseases that compromise the quality of life are extremely usefull in face to longest aging. We bring up an atualization about how vitamin D could take part on diabetes pathophysiology and some studies results.

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