哌唑嗪的解热活性。

Acta physiologica Polonica Pub Date : 1990-01-01
Z Szreder
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引用次数: 0

摘要

在5、19、28℃的3种环境温度(Ta)下,研究了热兔(大肠杆菌脂多糖,PLPS)对吡唑嗪(0.75 mg/kg,静脉注射或静脉滴注3 h)的热反应。这种解热活性伴随着抑制热产生或增强热消除,取决于Ta。提示哌唑嗪的解热作用主要是由体温调节系统的作用部分引起的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antipyretic activity of prazosin.

Thermal responses to prazosin (0.75 mg/kg, i.v. as a bolus injection or 3 h infusion) were investigated in febrile rabbits (treated with E. coli lipopolysaccharide, PLPS) at 3 ambient temperatures (Ta) of 5, 19, 28 degrees C. The drug produced antipyresis which increased with the simultaneous drop of Ta. This antipyretic activity was accompanied by an inhibition of heat production or enhanced elimination of heat, depending on Ta. It is suggested that antipyresis produced by prazosin is mainly due to the effector part of the thermoregulatory system.

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