糖皮质激素在NZB小鼠遗传决定的自身免疫病理发展中的可能参与。

Biomedical science Pub Date : 1991-01-01
V M Chesnokova, V L Chukhlib, E V Ignat'eva, L N Ivanova
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引用次数: 0

摘要

在自发发生自身免疫性疾病的雄性NZB小鼠中,测定了总血皮质酮浓度、肾上腺对外源性促肾上腺皮质激素的反应性以及皮质类固醇结合球蛋白(CBG)的结合能力。内源性红细胞抗体的出现也被监测。本研究对以下年龄组的动物进行了研究:(1)在自身抗体出现之前的2-3个月大的动物;(二)发病期间6-7月龄动物;(3) 10-12个月大的动物,即自身免疫性疾病发生的时期。结果表明,10-12月龄小鼠血浆中总皮质酮水平急剧下降(从152 +/- 32降至约20微克l-1),肾上腺对外源性促肾上腺皮质激素的反应性下降(从400%降至120%)。然而,随着年龄的增长,CBG的结合能力增加,导致血液中活性皮质酮的减少。这种能力的增加在10-12个月大的受影响动物中尤为明显。(结合位点数从0.64 +/- 0.05增加到0.8 +/- 0.03 microM,皮质酮与CBG结合的关联常数从0.29 +/- 0.05增加到0.91 +/- 0.07 microM-1)。上述变化的结合表明,在NZB小鼠糖皮质激素背景的减少与自身抗体的出现之间存在直接关联。(摘要删节250字)
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The possible involvement of glucocorticoids in the development of genetically determined autoimmune pathology in NZB mice.

The total blood corticosterone concentration, the reactivity of the adrenal glands to exogenous adrenocorticotrophic hormone, and the binding capacity of corticosteroid-binding globulin (CBG), were determined in male NZB mice that spontaneously develop an autoimmune disease. The appearance of antibodies to endogenous erythrocytes was also monitored. This study was performed on animals of the following age groups: (1) 2-3-month-old animals prior to the appearance of autoantibodies; (2) 6-7-month-old animals in the period when the disease developed; and (3) 10-12-month-old animals, i.e. the period when the autoimmune disease developed. It was demonstrated that in the 10-12-month-old mice there was a sharp decrease in the total corticosterone level in the plasma (from 152 +/- 32 to about 20 micrograms l-1), and the reactivity of the adrenal glands to exogenous corticotrophin decreased (from 400% to 120%). However, the binding capacity of CBG increased with age which led to a decrease in the pool of active corticosterone in the blood. The increase in this capacity was especially pronounced in affected 10-12-month-old animals. (The number of binding sites increased from 0.64 +/- 0.05 to 0.8 +/- 0.03 microM and the values of the association constant for the binding of corticosterone to CBG increased from 0.29 +/- 0.05 to 0.91 +/- 0.07 microM-1). The combination of the above-mentioned changes suggests that there is a direct correlation between the decrease in the glucocorticoid background in the NZB mice and in the appearance of autoantibodies.(ABSTRACT TRUNCATED AT 250 WORDS)

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