Low levels of HDL-cholesterol and endothelial dysfunction: a systematic review and meta-analysis

HDL-C is believed to retard the formation of atherosclerotic lesions by removing excess cholesterol from cells and preventing endothelial dysfunction. However, there are no systematic analyses or well-conducted meta-analyses to evaluate the relationship between very low HDL-C and endothelial dysfunction [1]. The of this study is to examine this association of very low HDL-C with endothelial dysfunction in different ages and This systematic review and meta-analysis will offer better understanding regarding the association between metabolic syndrome and endothelial dysfunction. The findings from this study will be useful for assessing of very low HDL-C and the risk factors in endothelial dysfunction, and determining approaches for prevention of endothelial dysfunction in the future. An improved understanding of this relationship may help to inform public health endothelial dysfunction prevention strategies. Included studies may have substantially different methodologies, which could limit our ability to draw reliable conclusions from the existing evidence base. Depending on the results, confounding factors that were not adjusted for the selected studies and low generalizability situations can be limitations. To minimize these limitations we will evaluate the heterogeneity between the studies, perform sensitivity analysis and meta-regression. : CIs Confidence HDL = high-density LDL = RR = risk