沙鼠种子保肝活性的潜力:计算机验证

Rizwan Mirza, Sunil Kumar, J. Malik
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引用次数: 0

摘要

一种被称为肝纤维化的伤口愈合是对由病毒、毒素和对肝脏有害的药物引起的慢性肝损伤的反应。该综合征的特点是炎症,随后是细胞外基质蛋白沉积和瘢痕组织的发展。Ephrin受体A2是一种与丙型肝炎病毒(HCV)进入(EphA2)相关的宿主辅助因子。麻瓜属麻瓜科。它含有谷甾醇、总酚、黄酮类化合物,具有抗氧化、抗菌和清除自由基的活性。杨梅素保肝作用的确切机制尚未揭示。为了提出杨梅素最可能的作用机制,我们对PPARα酶等肝保护药物靶点进行了对接计算分析。研究文章
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Potential of Hepatoprotective Activity of Abelmoschus Moschatus Seed: In-Silico Validation
A type of wound healing known as hepatic fibrosis arises in response to chronic liver damage brought on by viruses, toxins, and medications that are detrimental to the liver. The syndrome is characterized by inflammation, which is followed by the deposition of extracellular matrix proteins and the development of scar tissue. Ephrin receptor A2 is a host cofactor that has been associated to Hepatitis C virus (HCV) entry (EphA2). The Abelmoschus moschatus seed belong to family Malvaceae. It contains sitosterol b. total phenol, flavonoids which are responsible for antioxidant, antimicrobial and free radical scavenging activity. The exact mechanism of action for the hepatoprotective action of Myricetin was still not revealed. With intent to propose the most probable mechanism of action of Myricetin the docking based computational analysis has been performed against the hepatoprotective drug targets like PPARα enzyme. Research Article
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