O. Garbuz, I. Toderaș, Ia. I. Ulchina, V. Graur, Nadejda Railean, А. Gulea
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引用次数: 1
摘要
五个化合物2 - (2-Hydroxybenzylidene) - N - (prop-2-en1-yl) hydrazinecarbothioamide (H2L), bis(μ2 - 2 - ({2 - [(prop-2-en-1-yl) carbamothioyl] hydrazinylidene}甲基)phenolatoS, N, O, O] diaquadicopper硝酸(2)(1),bis(μ2 - 2 - ({2 - [(prop-2-en-1-yl) carbamothioyl] hydrazinylidene}甲基)phenolato-S, N, O, O] d iimidazoldicopper硝酸(2)(2),bis(μ2 - 2 - ({2 - [(prop-2en-1-yl) carbamothioyl] -hydrazinylidene}甲基)phenolato-S, N, O, O)双(3 5-dibromopyridine) dicopper六水合硝酸(2)(3),合成了双[μ2-2-({2-[(prop-2-en-1-酰基)氨基甲氧基]-肼基基}甲基)苯酚- s,N,O:O]双(4-甲基吡啶)二铜(II)硝酸六水合物(4)。研究了这些化合物对肿瘤细胞株HeLa、RD和正常细胞株MDCK的抗增殖作用。所测试的化合物对癌细胞表现出高抗氧化和抗增殖的选择性活性。采用大水蚤生物测定法直接评价化合物的毒性。
The Antiproliferative, Antioxidant Activities and Toxicity of Mixed-Ligand Amine-Containing Copper (II) Coordination Compounds with 2-(2-Hydroxybenzylidene)-N-(Prop-2-En-1-Yl) Hydrazinecarbothioamide
Five compounds 2-(2-Hydroxybenzylidene)-N-(prop-2-en1-yl)hydrazinecarbothioamide (H2L), bis[μ2-2-({2-[(prop-2-en-1-yl) carbamothioyl] hydrazinylidene}methyl) phenolatoS,N,O:O] diaquadicopper (II) nitrate (1), bis [μ2-2-({2-[(prop-2-en-1-yl) carbamothioyl] hydrazinylidene}methyl)phenolato-S,N,O:O]d iimidazoldicopper(II) nitrate (2), bis[μ2-2-({2-[(prop-2en-1-yl)carbamothioyl]-hydrazinylidene}methyl)phenolato-S,N,O:O]bis-(3,5-dibromopyridine)dicopper( II) nitrate hexahydrate (3), bis[μ2-2-({2-[(prop-2-en-1-yl)carbamothioyl]-hydrazinylidene}methyl) phenolato-S,N,O:O]bis(4-methylpyridine)dicopper(II) nitrate hexahydrate (4) were synthesized. The antiproliferative properties of these compounds towards cancer cell lines HeLa, RD and normal cell line MDCK have been investigated. The tested compounds demonstrated high antioxidant and antiproliferative, selective activities towards cancer cells. Direct toxic evaluation of compounds was performed by Daphnia magna bioassay.
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