9-苄基嘌呤抗鼻病毒活性的量子QSAR。

Drug design and delivery Pub Date : 1991-01-01

Y S Prabhakar

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引用次数: 0

摘要

利用Huckel分子轨道生成的电子参数和取代基的物理化学性质定量分析了先前描述的9-苄基嘌呤的抗鼻病毒活性。获得了对几种血清型病毒活性的相关性，但出现了很少的共同要求。我们的结果强调了鉴定具有最佳结构特征的化合物具有广谱抗鼻病毒活性的困难。

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Quantum QSAR of the antirhinoviral activity of 9-benzylpurines.

The antirhinoviral activity of previously described 9-benzylpurines was quantitatively analysed using Huckel molecular orbital generated electronic parameters and physicochemical properties of substituents. Correlations with the activity against each of several serotypes of the virus were obtained but very few common requirements emerged. Our results emphasise the difficulties in identifying a compound with optimum structural features for broad spectrum antirhinovirus activity.

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Drug design and delivery

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