Effects of Glutamine Peptide Supplementation on Lipolysis and Plasma IL-6 Concentration after Endurance Exercise

The purpose of this study was to investigate the effects of glutamine peptide supplementation on plasma interleukin-6 (IL-6), glucogenic amino acids and lipolytic metabolite during recovery after endurance exercise. In this crossover designed study, seven healthy male college students completed either placebo (PL) supplementation or glutamine peptide (GP) supplementation trial in a randomized order. The subjects were assigned to run on a treadmill at an estimated speed corresponding to their 75% V_4 O_2max values for 60 min, where after the GP trial received 0.1 g/kg ． bw glutamine-peptide solution and the PL trial received hydroxypropyl methylcellulose solution. The biochemical parameters in the blood sample were measured pre-exercise, and after exercise at 0, 15, 30, 45, 60, 90 and 120-min. Plasma IL-6 concentration was significantly greater in GP trial at 45 and 60 min during recovery periods. Furthermore, plasma glycerol was also significantly greater in GP trial during recovery at 60 and 90 min following exercise. Glucogenic amino acids in the GP trial were significantly increased at 30 min during recovery. Nevertheless, we found no significant differences in glucose, insulin and free fatty acid concentrations for both trials during recovery periods. In conclusion, the present study demonstrated that the GP supplementation can increase glucogenic amino acids, inhibit lipolysis and enhance plasma IL-6 concentrations in young adults during recovery following exercise.