{"title":"lc-ms对乳果糖-甘露醇肠道吸收回收率试验的改进","authors":"Raffaele Conte, A. Cavallo, Antonio Fico","doi":"10.35503/ijmlr.2019.4201","DOIUrl":null,"url":null,"abstract":"Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has seen enormous growth in clinical laboratories during the last decades due to the fact that it offers analytical specificity superior to that of immunoassays or conventional high performance liquid chromatography. Then, most chemicals and metabolites are now assayed by LC-MS/MS. The “Lactulose\\Mannitol recovery ratio (LAMA test)” is a non-invasive gastrointestinal test for the assessment of intestinal absorption and barrier function of the bowel. This article describes an optimized LC-MS/MS method used for the determination of these two sugars, characterized by rapidity, sensitivity, and easy automation.","PeriodicalId":420042,"journal":{"name":"International Journal of Medical Laboratory Research","volume":"124 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"IMPROVEMENT OF “LACTULOSE-MANNITOL RECOVERY RATIO TEST” OF INTESTINAL ABSORPTION BY LC-MS\\\\MS\",\"authors\":\"Raffaele Conte, A. Cavallo, Antonio Fico\",\"doi\":\"10.35503/ijmlr.2019.4201\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has seen enormous growth in clinical laboratories during the last decades due to the fact that it offers analytical specificity superior to that of immunoassays or conventional high performance liquid chromatography. Then, most chemicals and metabolites are now assayed by LC-MS/MS. The “Lactulose\\\\Mannitol recovery ratio (LAMA test)” is a non-invasive gastrointestinal test for the assessment of intestinal absorption and barrier function of the bowel. This article describes an optimized LC-MS/MS method used for the determination of these two sugars, characterized by rapidity, sensitivity, and easy automation.\",\"PeriodicalId\":420042,\"journal\":{\"name\":\"International Journal of Medical Laboratory Research\",\"volume\":\"124 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1900-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Medical Laboratory Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.35503/ijmlr.2019.4201\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Medical Laboratory Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35503/ijmlr.2019.4201","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
IMPROVEMENT OF “LACTULOSE-MANNITOL RECOVERY RATIO TEST” OF INTESTINAL ABSORPTION BY LC-MS\MS
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) has seen enormous growth in clinical laboratories during the last decades due to the fact that it offers analytical specificity superior to that of immunoassays or conventional high performance liquid chromatography. Then, most chemicals and metabolites are now assayed by LC-MS/MS. The “Lactulose\Mannitol recovery ratio (LAMA test)” is a non-invasive gastrointestinal test for the assessment of intestinal absorption and barrier function of the bowel. This article describes an optimized LC-MS/MS method used for the determination of these two sugars, characterized by rapidity, sensitivity, and easy automation.
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