表面活性剂复合物与DNA的相互作用研究:控制β-环糊精- DNA结合反应的疏水性

N. Karuppiah, Muthukumaran Pakkirisamy, G. Gladwin
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引用次数: 0

摘要

采用理化方法研究了阳离子表面活性剂配合物(phen = 1-10菲罗啉,TA=四环胺)顺式-[Co(phen)2(TA)2](ClO4)3与小牛胸腺DNA的相互作用。光谱研究、循环伏安法和粘度实验支持表面活性剂-钴(III)配合物通过脂肪链插入到DNA碱基对中与小牛胸腺DNA (CT DNA)结合。具有较大-框架结构的邻菲罗啉配体的存在也可能增强嵌入。此外,还研究了表面活性剂钴(III)配合物在-环糊精存在下与DNA结合的影响。在-环糊精存在的情况下,结合通过表面和(或)槽结合发生。该络合物作为一种潜在的络合物进行了研究
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Surfactant Complex Binding to DNA Interaction Study: Controlling Hydrophobicity in β-Cyclodextrin–DNA Binding Reactions
The interaction of cis-[Co(phen)2(TA)2](ClO4)3, a cationic surfactant complex (phen = 1-10 phenanthroline, TA= Tetradecylamine), with calf thymus DNA has been studied by physici-chemical techniques. The spectroscopic studies together with cyclic voltammetry and viscosity experiments support that the surfactant-cobalt(III) complex binds to calf thymus DNA (CT DNA) by intercalation through the aliphatic chain present in the complex into the base pairs of DNA. The presence of phenanthroline ligand with larger -frame work may also enhance intercalation. Besides the effect of binding of surfactant cobalt(III) complex to DNA in presence of -cyclodextrin has also studied. In presence of -cyclodextrin the binding occur through surface and (or) groove binding. The complex was investigated as one of the potential
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