{"title":"移植","authors":"L. Rees, N. Webb, D. Bockenhauer, M. Punaro","doi":"10.1093/med/9780198784272.003.0021","DOIUrl":null,"url":null,"abstract":"Kidney transplantation offers children with chronic kidney disease stage 5 the best chance of long-term survival and is associated with lower morbidity than long-term dialysis. However, transplantation surgery and the necessary long-term immunosuppressive therapy expose the child to an increased risk of a number of different complications, including infection, metabolic abnormalities, and malignancy. In the era of modern immunosuppressive therapy, acute rejection rates are low; however, there remain significant challenges regarding the management of recurrent disease and chronic antibody-mediated rejection.","PeriodicalId":415366,"journal":{"name":"Paediatric Nephrology","volume":"14 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Transplantation\",\"authors\":\"L. Rees, N. Webb, D. Bockenhauer, M. Punaro\",\"doi\":\"10.1093/med/9780198784272.003.0021\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Kidney transplantation offers children with chronic kidney disease stage 5 the best chance of long-term survival and is associated with lower morbidity than long-term dialysis. However, transplantation surgery and the necessary long-term immunosuppressive therapy expose the child to an increased risk of a number of different complications, including infection, metabolic abnormalities, and malignancy. In the era of modern immunosuppressive therapy, acute rejection rates are low; however, there remain significant challenges regarding the management of recurrent disease and chronic antibody-mediated rejection.\",\"PeriodicalId\":415366,\"journal\":{\"name\":\"Paediatric Nephrology\",\"volume\":\"14 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Paediatric Nephrology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/med/9780198784272.003.0021\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Paediatric Nephrology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/med/9780198784272.003.0021","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Kidney transplantation offers children with chronic kidney disease stage 5 the best chance of long-term survival and is associated with lower morbidity than long-term dialysis. However, transplantation surgery and the necessary long-term immunosuppressive therapy expose the child to an increased risk of a number of different complications, including infection, metabolic abnormalities, and malignancy. In the era of modern immunosuppressive therapy, acute rejection rates are low; however, there remain significant challenges regarding the management of recurrent disease and chronic antibody-mediated rejection.
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