TNF在炎性肠病发病机制中的作用

M. Perše, Ana Unkovič
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引用次数: 10

摘要

肿瘤坏死因子(TNF)是一种多效性细胞因子,参与多种病理过程,包括炎症性肠病(IBD)。过去,TNF被认为是一种具有有害作用的促炎细胞因子。这导致了抗肿瘤坏死因子药物的发展,从而彻底改变了克罗恩病等炎症性疾病的治疗。然而,在过去的20年里,临床研究表明抗tnf药物并不总是有效的。此外,在一些罕见的情况下,抗肿瘤坏死因子药物甚至会导致疾病的恶化。如今,越来越多的证据表明TNF不仅有害,而且在健康和维持体内平衡中发挥重要作用。本章的目的是简要总结证明TNF在IBD中复杂的二元作用的文献,并讨论抗TNF药物在IBD治疗中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Role of TNF in the Pathogenesis of Inflammatory Bowel Disease
Tumor necrosis factor (TNF) is a pleotropic cytokine involved in a wide range of pathological processes, including inflammatory bowel disease (IBD). In the past, TNF was recognized as a pro-inflammatory cytokine with deleterious effects. This has led to the development of anti-TNF drugs, which revolutionized the treatment of inflammatory disorders such as Crohn’s disease. However, in the past 20 years, clinical studies have shown that anti-TNF drugs are not always effective. Moreover, in some rare cases, anti-TNF drugs can even cause an aggravation of the disease. Nowadays, there is increasing evidence that TNF is not only detrimental but can also play an important role in health and the maintenance of homeostasis. The aim of this chapter is to briefly summarize the literature demonstrating the complex dichotomous role of TNF in IBD and discuss the role of anti-TNF drugs in the treatment of IBD.
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