鉴别癌前和正常口腔组织的自体荧光寿命

The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004. Pub Date : 2004-12-14 DOI:10.1109/APBP.2004.1412301

C. You, Hsin-Ming Chen, C. Chiang, Chin-Tin Chen, Chih-Yu Wang

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引用次数: 0

摘要

在这项研究中，我们评估了使用时间分辨自身荧光光谱来区分正常口腔黏膜(NOM)和口腔癌前病变(包括疣状增生(VH)、上皮增生(EH)和上皮异常增生(ED)的可行性。在633 nm处，在410 nm激发下，对15个VH、9个EH、14个ED和38个NOM样品进行时间分辨自体荧光测量，计算每次测量的双组分寿命，并构建二维散点图。采用Fisher判别分析(FDA)对4种组织进行分类。结果表明，71%的EH和VH、86%的ED和100%的NOM样品被正确鉴定。

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Autofluorescence lifetime for identifying premalignant and normal oral tissues

In this study, we evaluate the feasibility of using time-resolved autofluorescence spectroscopy for differentiating normal oral mucosa (NOM) from oral premalignant lesions including verrucous hyperplasia (VH), epithelial hyperplasia (EH), and epithelial dysplasia (ED). Time-resolved autofluorescence was measured at 633 nm under 410-nm excitation for 15 VH, 9 EH, 14 ED, and 38 NOM samples, and the two-component lifetimes for each measurement were calculated and a two-dimensional scatter plot was constructed. A Fisher's discriminant analysis (FDA) were used to classify the 4 types of tissues. The result showed that 71% of EH and VH, 86% of ED, and 100% of NOM samples were correctly identified.

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The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004.

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