{"title":"年龄和运动对雄性白化大鼠谷胱甘肽代谢的影响","authors":"C. Lakshmi, K. Indira","doi":"10.1080/15438620109512103","DOIUrl":null,"url":null,"abstract":"In the present study the effect of exercise on age‐induced alterations in glutathione metabolism has been investigated in the tissues of male albino rats. The activity of antioxidant enzymes of glutathione‐S‐transferase, glutathione reductase, glutathione peroxidase, enzymes of oxidative metabolism glucose‐6‐phosphate dehydrogenase, succinate dehydrogenase and reduced glutathione, a biological antioxidant, were estimated in selected tissues. These enzymes showed a general decline with advancement of age. Further, endurance exercise increased the activity of these enzymes in both young and aged rats in all the three tissues studied. The increased activity of antioxidant enzymes and the GSH‐GSSG redox cycle during exercise training suggests a novel defensive mechanism in response to increased free radical production during aging.","PeriodicalId":403174,"journal":{"name":"Sports Medicine, Training and Rehabilitation","volume":"118 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Age and exercise induced changes in glutathione metabolism of male albino rats\",\"authors\":\"C. Lakshmi, K. Indira\",\"doi\":\"10.1080/15438620109512103\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In the present study the effect of exercise on age‐induced alterations in glutathione metabolism has been investigated in the tissues of male albino rats. The activity of antioxidant enzymes of glutathione‐S‐transferase, glutathione reductase, glutathione peroxidase, enzymes of oxidative metabolism glucose‐6‐phosphate dehydrogenase, succinate dehydrogenase and reduced glutathione, a biological antioxidant, were estimated in selected tissues. These enzymes showed a general decline with advancement of age. Further, endurance exercise increased the activity of these enzymes in both young and aged rats in all the three tissues studied. The increased activity of antioxidant enzymes and the GSH‐GSSG redox cycle during exercise training suggests a novel defensive mechanism in response to increased free radical production during aging.\",\"PeriodicalId\":403174,\"journal\":{\"name\":\"Sports Medicine, Training and Rehabilitation\",\"volume\":\"118 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2001-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sports Medicine, Training and Rehabilitation\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/15438620109512103\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sports Medicine, Training and Rehabilitation","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/15438620109512103","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
在本研究中，研究了运动对年龄诱导的雄性白化大鼠组织中谷胱甘肽代谢改变的影响。测定了选定组织中谷胱甘肽- S -转移酶、谷胱甘肽还原酶、谷胱甘肽过氧化物酶、氧化代谢酶葡萄糖- 6 -磷酸脱氢酶、丁二酸脱氢酶和还原性谷胱甘肽(一种生物抗氧化剂)的抗氧化酶活性。这些酶随着年龄的增长而普遍下降。此外，耐力运动增加了这些酶在年轻和老年大鼠所有三种组织中的活性。运动训练中抗氧化酶活性的增加和GSH - GSSG氧化还原循环的增加提示了衰老过程中自由基产生增加的一种新的防御机制。
Age and exercise induced changes in glutathione metabolism of male albino rats
In the present study the effect of exercise on age‐induced alterations in glutathione metabolism has been investigated in the tissues of male albino rats. The activity of antioxidant enzymes of glutathione‐S‐transferase, glutathione reductase, glutathione peroxidase, enzymes of oxidative metabolism glucose‐6‐phosphate dehydrogenase, succinate dehydrogenase and reduced glutathione, a biological antioxidant, were estimated in selected tissues. These enzymes showed a general decline with advancement of age. Further, endurance exercise increased the activity of these enzymes in both young and aged rats in all the three tissues studied. The increased activity of antioxidant enzymes and the GSH‐GSSG redox cycle during exercise training suggests a novel defensive mechanism in response to increased free radical production during aging.
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