卵胞浆内单精子注射成功治疗夫妻不育症的相关因素

R. D. Nunes, T. Vieira, J. Traebert
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摘要

目的:胞浆内单精子注射(ICSI)后获得和维持妊娠可能受到许多技术因素的影响。本研究的目的是确定ICSI技术与既定参数的成功率,并评估其成功治疗不孕症的相关因素。方法:从2013年7月至2014年12月,对115对接受ICSI的不育夫妇进行横断面研究,以测试技术方面与成功率之间的关系。数据收集是通过医疗记录完成的。通过患病率计算双变量相关性,并进行泊松回归,显著性水平p < 0.05。结果:输注8个及以上卵母细胞与妊娠存活率的相关性降低0.73倍(CI 95% 0.57 ~ 0.94) (p = 0.014),输注2个及以上卵母细胞与妊娠存活率的相关性提高1.75倍(CI 95% 1.54 ~ 1.99) (p < 0.001)。ICSI手术的其余特征与预期结果没有显著相关。结论:ICSI术后活胎率为40.9%。卵母细胞少于8个和移植2个或2个以上胚胎对该指标有正向影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Factors associated with the success of intracytoplasmic sperm injection for the treatment of conjugal infertility
Objectives: Obtaining and maintaining pregnancy after intracytoplasmic sperm injection (ICSI) may be affected by many technical factors. The goal of this study is to determine the rates of success from ICSI technique with established parameters and assess the associated factors to its success to treat infertility. Methods: A cross-sectional study involving 115 infertile couples submitted to ICSI was performed to test the association between technical aspects and success rates, from July 2013 to December 2014. Data collection was done through medical records. The bivariate associations were calculated by prevalence ratios and a Poisson regression was performed with significance level p < 0.05. Results: The aspiration of eight or more oocytes was 0.73 times (CI 95% 0.57-0.94) less associated (p = 0.014), but transferring two or more embryos was 1.75 times (CI 95% 1.54-1.99) more associated with the viable pregnancy (p < 0.001). The remaining characteristics of the ICSI procedures were not significantly associated with the expected outcome. Conclusions: The prevalence of the viable pregnancy after ICSI procedure was 40.9%. This index was positively influenced by the aspiration of less than eight oocytes and the transferring of two or more embryos.
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