FEATURES OF THE PATHOGENESIS OF PURULENT WOUNDS OF THE LOWER EXTREMITIES THAT DO NOT HEAL FOR A LONG TIME

Summary. The article deals with the current state of the pathogenesis of purulent wounds of the lower extremities that do not heal for a long time. According to the studied sources of literature of domestic and foreign authors, the mechanisms of matrix synthesis and the remodelling phase, the role of cytokines in the inflammatory response, as well as the participation of nitric oxide in the reaction with hydroxyl free radicals to form peroxide nitrate, a reactive free radical with the ability to cause tissue destruction and induce apoptosis, are revealed. In conclusion, it is possible to state the interest of researchers in the problem of pathogenesis and note the relevance of the study for further developments to improve the complex treatment of patients with lower extremity APRTN.