高密度脂蛋白与心血管疾病

S. Nicholls, H. Brown, K. Bubb
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引用次数: 4

摘要

在寻找新的心脏保护疗法的过程中,人们对靶向高密度脂蛋白(HDL)生物学功能的方法非常感兴趣。这是基于人群和动物研究的数据,表明HDL对心血管风险具有潜在的保护作用。最近一系列旨在促进HDL的治疗干预的临床试验结果令人失望,并且对这一目标的潜在效用提出了相当大的不确定性。最近的证据强调了高密度脂蛋白功能的重要性,这可能最终与心血管风险相关。这导致人们不断努力开发新的风险标志物和治疗方法,重点关注HDL的质量而不是数量。本文综述了支持高密度脂蛋白保护作用的证据和高密度脂蛋白靶向治疗的临床试验结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High-Density Lipoproteins and Cardiovascular Disease
In the search to develop new cardioprotective therapies, considerable interest has focussed on approaches for targeting the biological functions of high-density lipoproteins (HDL). This is based on data from population and animal studies demonstrating a potentially protective impact of HDL on cardiovascular risk. The findings of recent clinical trials of a range of therapeutic interventions aimed at promoting HDL have been disappointing and raise considerable uncertainty regarding the potential utility of this target. More recent evidence has highlighted the importance of HDL functionality, which may ultimately be important in terms of its association with cardiovascular risk. This has led to ongoing efforts to develop new risk markers and therapeutics focussing on HDL quality as opposed to quantity. The evidence supporting a protective role for HDL and findings of clinical trials of HDL-targeted therapies are reviewed here.
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