使用skip-gram模型发现潜在的药物不良反应

Mingzhen Zhao, Bo Xu, Hongfei Lin, Zhihao Yang, Jian Wang
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引用次数: 2

摘要

近年来,药品不良反应(adr)严重影响了人们的健康,药品不良事件报告系统成为监测药品安全的重要手段,医疗卫生专业人员或药品消费者可以根据自己的经验或专业知识提交药品不良事件报告。然而,随着药物的增加,提交的报告数量迅速增加,手动捕获所有adr变得越来越困难。为了解决这个问题,我们开发了一个新的系统来自动计算药物之间的相似度和不良反应。在该方法中,我们使用skip-gram模型将药物和不良反应的提及次数表示为分布向量,并根据相似度发现最潜在的药物不良反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Discover potential adverse drug reactions using the skip-gram model
In these years, the adverse drug reactions (ADRs) have seriously impacted the people's health, and adverse drug event reporting systems become a key means to monitor the drug safety, in which healthcare professionals or drug consumers can submit the adverse drug event reports based on their experience or professional knowledge. However, with the increase of drugs, the number of the submitted reports increases rapidly, making it more and more difficult to capture all the ADRs manually. To tackle the problem, we develop a novel system to compute the similarities among the drugs and adverse reactions automatically from the reports. In the method, we represent the mentions of drugs and adverse reactions as distributed vectors using the skip-gram model, and discover the most potential adverse drug reactions based on the similarities.
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