Open issues with last wave of COVID-19 pandemic: a commentary regarding frail patients and non-responders to vaccination in clinical practice

The year 2021 was next to finish and the year 2022 began and the world fighting the pandemic due to SARS-CoV-2.The clinical scenario is now really different from the onset of pandemic after first waves of vaccinations campaign. Severe lung failures are less frequent the vaccination campaign and because the presence of COVID-19 variant’ of concern that seem to be less virulent, in particular B.1.1.529 (Omicron)., severe lung failures may be found in anti Vax people and in immunocompromised patients because immunological toward SARS-CoV2.Furthermore, because the presence of less virulent lately, we are observing more frequently patients with positive nasopharyngeal swab to SARS-CoV-2 and with acute medical diseases but without interstitial pneumonia COVID-19. These unfortunately induce frequent difficulties to the internal and external triage system, also to the collocation and distribution of patients positive to SARS-CoV-2 or without COVID-19 into the hospital.